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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic susceptibility to MS: A second stage analysis in Canadian MS families
Neurogenetics, Volume 3, No. 3, Year 2001
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Description
Four published genome screens have identified a number of markers with increased sharing in multiple sclerosis (MS) families, although none has reached statistical significance. One hundred and five markers previously identified as showing increased sharing in Canadian, British, Finnish, and American genome screens were genotyped in 219 sibling pairs ascertained from the database of the Canadian Collaborative Project on Genetic Susceptibility to MS (CCPGSMS). No markers examined met criteria for significant linkage. Markers located at 5p14 and 17q22 were analyzed in a total of 333 sibling pairs and attained mlod scores of 2.27 and 1.14, respectively. The known HLA Class II DRB1 association with MS was confirmed (P<0.0001). Significant transmission disequilibrium was also observed for D17S789 at 17q22 (P=0.0015). This study highlights the difficulty of searching for genes with only mild-to-moderate effects on susceptibility, although large effects of specific loci may still be present in individual families. Future progress in the genetics of this complex trait may be helped by (1) focussing on more ethnically homogeneous samples, (2) using an increased number of MS families, and (3) using transmission disequilibrium analysis in candidate regions rather than the affected relative pair linkage analysis. © Springer-Verlag 2001.
Authors & Co-Authors
Dyment, David Alexandre
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Willer, Cristen J.
United Kingdom, Oxford
The Wellcome Centre for Human Genetics
Hillert, Jan A.
Sweden, Stockholm
Karolinska Institutet
Oger, Joel J.
Canada, Vancouver
The University of British Columbia
Metz, Luanne M.
Canada, Calgary
University of Calgary
Warren, Sharon A.
Canada, Edmonton
University of Alberta
Power, Christopher
Canada, Winnipeg
University of Manitoba
Nath, Avindra
Canada, Winnipeg
University of Manitoba
Nelson, Robert F.
Canada, Ottawa
University of Ottawa
Freedman, Mark Steven
Canada, Ottawa
University of Ottawa
O'Connor, Paul W.
Canada, Toronto
University of Toronto
Canada, London
Western University
Duquette, Pierre Pascal
Canada, Montreal
University of Montreal
Bouchard, Jean Pierre
Canada, Quebec
Université Laval
Sadovnick, Adele Dessa
Canada, Vancouver
The University of British Columbia
Risch, Neil J.
United States, Palo Alto
Stanford University
Statistics
Citations: 37
Authors: 15
Affiliations: 18
Identifiers
Doi:
10.1007/s100480100113
ISSN:
13646745
Research Areas
Genetics And Genomics