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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influence of the clinical status on stress reticulocytes, CD 36 and CD 49d of SSFA
2
homozygous sickle cell patients followed in Abidjan
Advances in Hematology, Volume 2014, Article 273860, Year 2014
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Description
Background and Objectives. Interactions between sickle cells involving CD 49d, CD36, and the vascular endothelium may initiate vasoocclusion leading to acute painful episodes and multiple organ failure. Materials and Methods. We selected 60 SS patients who had never been treated by hydroxyurea. We performed a total blood count. We identified with immunophenotyping by flow cytometry total reticulocytes their distribution according to the degree of maturity (mature, intermediate, very immature) and CD 36+ and CD 49d + antigens. Stress reticulocytes corresponded to the sum of intermediate and immature cells. Results. Subjects in crisis had more total reticulocytes and very immature reticulocytes than subjects in stationary phase (P<0.05). During the crisis, total CD 36+ reticulocytes (214 870 ± 107 584/L versus 148 878 ± 115 024/L; P<0.05) and the very immature CD 36+ reticulocytes (28.9 ± 7.9% versus 23.0 ± 6.4%; P<0.05) increased. The clinical status had no impact on CD 49d+ reticulocytes. Conclusion. The rates of stress reticulocytes in general and those expressing CD 49d and CD 36 were very high. The clinical status had an influence on CD 36+ reticulocytes. The expression of adhesion molecules is only one of the parameters involved in sickle cell disease crisis. © 2014 Duni Sawadogo et al.
Authors & Co-Authors
Sawadogo, Duni
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Teaching Hospital of Yopougon
Tolo-Dilkébié, Aïssata
Cote D'ivoire, Abidjan
Teaching Hospital of Yopougon
Sangaré, Mahawa
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Cote D'ivoire, Abidjan
Teaching Hospital of Yopougon
Aguéhoundé, Nelly
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Kassi, Hermance
Cote D'ivoire, Abidjan
Teaching Hospital of Yopougon
Latte, Toussaint
Cote D'ivoire, Abidjan
Teaching Hospital of Yopougon
Statistics
Citations: 14
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1155/2014/273860
ISSN:
16879104
e-ISSN:
16879112