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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility
Fertility and Sterility, Volume 79, No. SUPPL. 3, Year 2003
Notification
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Description
Objective: To examine the effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Design: Prospective study. Setting: Infertility clinic at a tertiary care academic institution. Patient(s): Ninety-two infertile men with normal female partners. Sixteen fertile donors served as the control group. Intervention(s): Standard semen analysis and assessment of levels of seminal oxidative stress. Assisted reproductive techniques in 33 of the 92 patients (IUI [n = 19], IVF [n = 10], and intracytoplasmic sperm injection [n = 4]). Main Outcome Measure(s): Sperm DNA damage by sperm chromatin structure assay. Results were expressed as DNA fragmentation index. Result(s): Patients were classified as having either idiopathic (n = 23) or male factor infertility (n = 69). Patients with idiopathic and male factor infertility had significantly higher DNA fragmentation index and oxidative stress compared with the case of fertile donors. A clinical pregnancy was achieved in 9 (27%) of 33 patients with assisted reproductive techniques. Significantly higher DNA fragmentation index and oxidative stress were found in men who failed to initiate a pregnancy after assisted reproductive techniques (n = 24), compared with the cases of those who succeeded and of the fertile donors. DNA fragmentation index was correlated positively with oxidative stress (r = 0.27), and negatively with fertilization (r = -0.70) and embryo quality (r = -0.70). Conclusion(s): Sperm DNA damage is significantly increased in men with idiopathic and male factor infertility and in men who failed to initiate a pregnancy after assisted reproductive techniques. Such an increase may be related to high levels of seminal oxidative stress. © 2003 by American Society for Reproductive Medicine.
Authors & Co-Authors
Saleh, Ramadan Abdou
United States, Cleveland
Cleveland Clinic Foundation
United States, Cleveland
Center for Advanced Research in Human Reproduction
Egypt, Sohag
Sohag University
Agarwal, Ashok K.
United States, Cleveland
Cleveland Clinic Foundation
United States, Cleveland
Center for Advanced Research in Human Reproduction
Nada, E. A.
United States, Cleveland
Cleveland Clinic Foundation
Egypt, Sohag
Sohag University
El-Tonsy, Mohammed H.
United States, Cleveland
Cleveland Clinic Foundation
Egypt, Minya
Minia University
Sharma, Rakesh Kumar
United States, Cleveland
Cleveland Clinic Foundation
United States, Cleveland
Center for Advanced Research in Human Reproduction
Meyer, Andrew D.
United States, Cleveland
Cleveland Clinic Foundation
United States, Cleveland
Center for Advanced Research in Human Reproduction
Nelson, David R.
United States, Cleveland
Cleveland Clinic Foundation
Thomas, Anthony Joseph
United States, Cleveland
Cleveland Clinic Foundation
United States, Cleveland
Center for Advanced Research in Human Reproduction
Statistics
Citations: 450
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/S0015-0282(03)00337-6
ISSN:
00150282
Research Areas
Genetics And Genomics
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Randomised Control Trial
Cohort Study
Participants Gender
Male
Female