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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Strategies to manage hepatitis C virus (HCV) disease burden
Journal of viral hepatitis, Volume 21, Year 2014
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Description
The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. The largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical. © 2014 John Wiley & Sons Ltd.
Authors & Co-Authors
Wedemeyer, Heiner
Germany, Hannover
Hannover Medical School
Duberg, Ann Sofi
Germany, Hannover
Hannover Medical School
Butí, María Asunción
Germany, Hannover
Hannover Medical School
Fraňková, Soňa
Germany, Hannover
Hannover Medical School
Esmat, Gamal
Germany, Hannover
Hannover Medical School
Örmeci, Necati
Germany, Hannover
Hannover Medical School
Gschwantler, Michael
Germany, Hannover
Hannover Medical School
Akarca, Ulus Salih
Germany, Hannover
Hannover Medical School
Aleman, Soo
Germany, Hannover
Hannover Medical School
Berg, Thomas
Germany, Hannover
Hannover Medical School
Bihl, Florian K.
Germany, Hannover
Hannover Medical School
Bilodeau, Marc
Germany, Hannover
Hannover Medical School
Blasco, Antonio Javier
Germany, Hannover
Hannover Medical School
Brandão-Mello, Carlos Eduardo
Germany, Hannover
Hannover Medical School
Bruggmann, Philip
Germany, Hannover
Hannover Medical School
Calinas, Filipe
Germany, Hannover
Hannover Medical School
Calleja-Panero, José Luis
Germany, Hannover
Hannover Medical School
Cheinquer, Hugo
Germany, Hannover
Hannover Medical School
Christensen, Peer Brehm
Germany, Hannover
Hannover Medical School
Clausen, Mette Rye
Germany, Hannover
Hannover Medical School
Cornberg, Markus
Germany, Hannover
Hannover Medical School
Cramp, M. E.
Germany, Hannover
Hannover Medical School
Dore, Gregory J.
Germany, Hannover
Hannover Medical School
Doss, Wahid H.
Germany, Hannover
Hannover Medical School
El-Sayed, Manal Hamdy
Germany, Hannover
Hannover Medical School
Ergor, Gul
Germany, Hannover
Hannover Medical School
Estes, Chris R.
Germany, Hannover
Hannover Medical School
Falconer, Karolin
Germany, Hannover
Hannover Medical School
Ferraz, Maria Lucia Gomes Lúcia Gomes
Germany, Hannover
Hannover Medical School
Ferreira, Paulo Roberto Abrão
Germany, Hannover
Hannover Medical School
García-Samaniego, Javier
Germany, Hannover
Hannover Medical School
Gerstoft, Jan
Germany, Hannover
Hannover Medical School
Gonçales, Fernando Lopes
Germany, Hannover
Hannover Medical School
Pessoa, Mário Guimarães
Germany, Hannover
Hannover Medical School
Heźode, Christophe
Germany, Hannover
Hannover Medical School
Blach, Sarah
Germany, Hannover
Hannover Medical School
Hofer, Harald O.
Germany, Hannover
Hannover Medical School
Husa, Petr
Germany, Hannover
Hannover Medical School
Idilman, Ramazan
Germany, Hannover
Hannover Medical School
Kåberg, Martin
Germany, Hannover
Hannover Medical School
Kautz, Achim
Germany, Hannover
Hannover Medical School
Kaymakoĝlu, Sabahattin
Germany, Hannover
Hannover Medical School
Krajden, Mel
Germany, Hannover
Hannover Medical School
Krarup, Henrik B.
Germany, Hannover
Hannover Medical School
Laleman, Wim J.
Germany, Hannover
Hannover Medical School
Lavanchy, Daniel
Germany, Hannover
Hannover Medical School
Marinho, Rui Tato
Germany, Hannover
Hannover Medical School
Marotta, Paul J.
Germany, Hannover
Hannover Medical School
Mendes-Corrěa, Maria Cássia Jacintho
Germany, Hannover
Hannover Medical School
Moreno, Christophe
Germany, Hannover
Hannover Medical School
Mul̈lhaupt, Beat
Germany, Hannover
Hannover Medical School
Peltekian, Kevork Minas
Germany, Hannover
Hannover Medical School
Ramji, Alnoor S.
Germany, Hannover
Hannover Medical School
Razavi, Homie A.
Germany, Hannover
Hannover Medical School
Roberts, Stuart Keith
Germany, Hannover
Hannover Medical School
Roudot-Thoraval, Françoise
Germany, Hannover
Hannover Medical School
Sarrazin, Christoph M.
Germany, Hannover
Hannover Medical School
Semela, David
Germany, Hannover
Hannover Medical School
Shiha, Gamal Elsayed
Germany, Hannover
Hannover Medical School
Star̈kel, Peter
Germany, Hannover
Hannover Medical School
Stauber, Rudolf E.
Germany, Hannover
Hannover Medical School
Thompson, Alex Cargill
Germany, Hannover
Hannover Medical School
Van-Damme, Pierre A.
Germany, Hannover
Hannover Medical School
Vogel, Wolfgang
Germany, Hannover
Hannover Medical School
Waked, I. A.
Germany, Hannover
Hannover Medical School
Weis, Nina M.
Germany, Hannover
Hannover Medical School
Wiegand, Johannes
Germany, Hannover
Hannover Medical School
Yosry, Ayman
Germany, Hannover
Hannover Medical School
Negro, Francesco
Germany, Hannover
Hannover Medical School
Sievert, William
Germany, Hannover
Hannover Medical School
Gower, Erin E.
Germany, Hannover
Hannover Medical School
Statistics
Citations: 347
Authors: 71
Affiliations: 1
Identifiers
Doi:
10.1111/jvh.12249
ISSN:
13652893
Research Areas
Infectious Diseases