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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia
Asian Pacific Journal of Tropical Biomedicine, Volume 3, No. 7, Year 2013
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Description
Objective: To assess the magnitude and antimicrobial susceptibility patterns of Streptococcus pneumoniae isolates from various clinical specimens. Methods: A record based on retrospective study was conducted at Gondar University Teaching Hospital from September 2007 to January 2012. All patients who visited Gondar University Hospital and provided clinical specimens (body fluids, discharge, swab and blood) for routine bacteriological culturing and antimicrobial susceptibility testing were taken for analysis. Clinical specimens were processed for bacterial culture according to the standard procedures. Antimicrobial susceptibility test for isolated organisms was done using agar disk diffusion method. The data were entered and analyzed using SPSS software version 16 package. Results: One hundred and fifty three Streptococcus pneumoniae were isolated from patients who visited Gondar University Teaching Hospital bacteriology laboratory for culture. Majority of the pneumococcal isolates were from inpatients [111(72.5%)], and 74(48.4%) were from body fluids. Out of the total isolates, 93(61%) were found to be resistant to at least one antibiotic used for susceptibility testing. Forty eight (43.2%) of the isolates were multi-drug resistant (resistant to two or more drugs). The resistance rate noted for both ciprofloxacin 17(11.1%) and ceftriaxone 15(9.8%) were alarming. Conclusions: High proportions of the isolates tend to be increasingly resistant to the commonly prescribed drugs. The recommended drug of choice like ciprofloxacin and ceftriaxone were found to be less susceptible in the study area. Based on the findings, we therefore recommend that antimicrobial agents should be inspected for acceptable activity before they are prescribed and administered empirically. Further study with a better design and survey of antimicrobial susceptibility at large scale shoule be performed to draw advanced information. © 2013 Asian Pacific Tropical Biomedical Magazine.
Authors & Co-Authors
Anagaw, Belay
Ethiopia, Gondar
University of Gondar
Gezachew, Mucheye
Ethiopia, Gondar
University of Gondar
Biadgelgene, Fantahun
Ethiopia, Bahir Dar
Bahir Dar University
Germany, Leipzig
Universität Leipzig
Anagaw, Berhanu
Ethiopia, Addis Ababa
Addis Ababa University
Geleshe, Tariku
Ethiopia, Gondar
University of Gondar
Taddese, Birke
Ethiopia, Gondar
University of Gondar
Getie, Birhanu
Ethiopia, Gondar
University of Gondar
Endris, Mengistu
Ethiopia, Gondar
University of Gondar
Mulu, A.
Ethiopia, Gondar
University of Gondar
Germany, Leipzig
Universität Leipzig
Unakal, Chandrashekhar G.
Ethiopia, Gondar
University of Gondar
Statistics
Citations: 14
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1016/S2221-1691(13)60109-4
ISSN:
22211691
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Ethiopia