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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
environmental science
Cadmium impact and osteoporosis: Mechanism of action
Toxicology Mechanisms and Methods, Volume 22, No. 7, Year 2012
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Description
Context: Cadmium (Cd) is a widespread environmental pollutant that is associated with increased risk of osteoporosis. It has been proposed that Cd's toxic effect on bone is exerted via impaired activation of vitamin D, secondary to the kidney effects. Objective: The present study was designed to investigate the damaging impact of Cd in drinking water on bone from biochemical and histopathological point of view. Materials and methods: This study was conducted on 30, 3-months-old female Sprague Dawley rats exposed to cadmium chloride in a dose of 50mg Cd/L in drinking water for 3 months. Serum was taken for determination of calcium, phosphorous levels, parathyroid hormone, 1,25 dihydroxy vitamin D3, osteocalcin (OC) and bone specific alkaline phosphatase (BALP) activity. Results: The result revealed that Cd administration induces significant increase in serum calcium (Ca), phosphorous (P) and parathyroid hormone (PTH) levels in concomitant with significant reduction in serum vitamin D3, osteocalcin (OC) levels and bone specific alkaline phosphatase (BALP) activity. Conclusion: The present study provided clear evidence that long-term exposure to cadmium chloride produced marked abnormalities in bone biomarkers and increasing risk of fracture. © 2012 Informa Healthcare USA, Inc.
Authors & Co-Authors
Youness, Eman R.
Egypt, Giza
National Research Centre
Mohammed, Nadia A.
Egypt, Giza
National Research Centre
Morsy, Fatma Adly
Egypt, Giza
National Research Centre
Statistics
Citations: 65
Authors: 3
Affiliations: 1
Identifiers
Doi:
10.3109/15376516.2012.702796
ISSN:
15376516
e-ISSN:
15376524
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Participants Gender
Female