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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Extensive ethnogenomic diversity of endothelial nitric oxide synthase (eNOS) polymorphisms
Gene Regulation and Systems Biology, Volume 2013, No. 1, Year 2013
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Description
Nitric oxide (NO) is highly reactive, produced in endothelial cells by endothelial NO synthase (eNOS) and has been implicated in sickle cell pathophysiology. We evaluated the distribution of functionally significant eNOS variants (the T786C variant in the promoter region, the Glu298Asp variant in exon 7, and the variable number of tandem repeats (VNTR) in intron 4) in Africans, African Americans and Caucasians. The C-786 variant was more common in Caucasians than in Africans and African Americans. Consistent with other findings, the Asp-298 variant had the highest frequency in Caucasians followed by African Americans, but was completely absent in Africans. The very rare intron 4 allele, eNOS 4c, was found in some Africans and African Americans, but not in Caucasians. eNOS 4d allele was present in 2 Africans. These findings suggest a consistent and widespread genomic diversity in the distribution of eNOS variants in Africans, comparative to African Americans and Caucasians. © the author(s), publisher and licensee Libertas Academica Ltd.
Authors & Co-Authors
Thomas, Bolaji Nun
United States, Rochester
Rochester Institute of Technology
Thakur, Tanya J.
United States, Rochester
Rochester Institute of Technology
Yi, Li
China, Taiyuan
Shanxi University of Finance and Economics
Guindo, Aldiouma
Mali, Bamako
Sickle Cell Disease Research and Control Center Crld
Diallo, Dapa Aly
Mali, Bamako
Sickle Cell Disease Research and Control Center Crld
Ott, Jürg
China, Beijing
Institute of Psychology Chinese Academy of Sciences
United States, New York
Rockefeller University
Statistics
Citations: 27
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.4137/GRSB.S10857
Research Areas
Genetics And Genomics