Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
Bioorganic and Medicinal Chemistry, Volume 18, No. 23, Year 2010
Notification
URL copied to clipboard!
Description
A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro antimalarial activity. The Cu(I)-catalyzed cycloaddition of azides and terminal alkynes was applied as the hybridization strategy. Several chalcone-chloroquinoline hybrid compounds were found to be notably active, with compound 8b the most active, exhibiting submicromolar IC50 values against the D10, Dd2 and W2 strains of Plasmodium falciparum. © 2010 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Guantai, Eric
South Africa, Cape Town
University of Cape Town
Ncokazi, Kanyile
South Africa, Cape Town
University of Cape Town
Egan, Timothy John
South Africa, Cape Town
University of Cape Town
Gut, Jiří
United States, San Francisco
Ucsf School of Medicine
Rosenthal, Philip Jon
United States, San Francisco
Ucsf School of Medicine
Smith, Peter John
South Africa, Cape Town
University of Cape Town
Chibale, Kelly
South Africa, Cape Town
University of Cape Town
Statistics
Citations: 177
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1016/j.bmc.2010.10.009
ISSN:
09680896
Research Areas
Genetics And Genomics