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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
The CD45 locus in cattle: Allelic polymorphism and evidence for exceptional positive natural selection
Immunogenetics, Volume 52, No. 3-4, Year 2001
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Description
Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, and a third ascribed to an indigenous African sub-species of cattle. Due to their extended co-evolution, indigenous African herbivores are generally tolerant to endemic African pathogens. We are interested in identifying alleles derived from the indigenous African cattle that may be associated with tolerance to African pathogens. An analysis of the locus which encodes the abundant plasma membrane-associated tyrosine phosphatase, CD45, identified three highly divergent allelic families in Kenya Boran cattle. Analysis of allelic distribution in a diverse range of cattle populations suggests a European B. taurus, an Asian B. indicus, and an African origin. This demonstrates not only significant allelic polymorphism at the CD45 locus in cattle but also convincing autosomeal evidence for a distinct African sub-species of cattle. Furthermore, maximum-likelihood analysis of selection pressures revealed that the CD45 locus is subject to exceptionally strong natural selection which we suggest may be pathogen driven. © Springer-Verlag 2000.
Authors & Co-Authors
Ballingall, Keith T.
Kenya, Nairobi
International Livestock Research Institute Nairobi
United Kingdom, Midlothian
Moredun Research Institute
Waibochi, Lillian
Kenya, Nairobi
International Livestock Research Institute Nairobi
Holmes, Edward C.
United Kingdom, Oxford
University of Oxford
Woelk, Christopher H.
United Kingdom, Oxford
University of Oxford
MacHugh, Niall D.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Lutje, Vittoria
Kenya, Nairobi
International Livestock Research Institute Nairobi
McKeever, Declan J.
Kenya, Nairobi
International Livestock Research Institute Nairobi
Statistics
Citations: 23
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1007/s002510000276
ISSN:
00937711
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Kenya