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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Antimicrobial, antioxidant and cytotoxic activities and phytochemical screening of some yemeni medicinal plants
Evidence-based Complementary and Alternative Medicine, Volume 7, No. 3, Year 2010
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Description
The traditional medicine still plays an important role in the primary health care in Yemen. The current study represents the investigation of 16 selected plants, which were collected from different localities of Yemen. The plants were dried and extracted with two different solvents (methanol and hot water) to yield 34 crude extracts. The obtained extracts were tested for their antimicrobial activity against three Gram-positive bacteria, two Gram-negative bacteria, one yeast species and three multiresistant Staphylococcus strains using agar diffusion method, for their antioxidant activity using scavenging activity of DPPH radical method and for their cytotoxic activity using the neutral red uptake assay. In addition, a phytochemical screening of the methanolic extracts was done. Antibacterial activity was shown only against Gram-positive bacteria, among them multiresistant bacteria. The highest antimicrobial activity was exhibited by the methanolic extracts of Acalypha fruticosa, Centaurea pseudosinaica, Dodonaea viscosa, Jatropha variegata, Lippia citriodora, Plectranthus hadiensis, Tragia pungens and Verbascum bottae. Six methanolic extracts especially those of A. fruticosa, Actiniopteris semiflabellata, D. viscosa, P. hadiensis, T. pungens and V. bottae showed high free radical scavenging activity. Moreover, remarkable cytotoxic activity against FL-cells was found for the methanolic extracts of A. fruticosa, Iris albicans, L. citriodora and T. pungens. The phytochemical screening demonstrated the presence of different types of compounds like flavonoids, terpenoids and others, which could be responsible for the obtained activities. © 2008 The Author(s).
Authors & Co-Authors
Mothana, Ramzi Ahmed A.
Yemen, Sana'a
Sana'a University
Abdo, Salah A.
Yemen, Sana'a
University of Science and Technology
Hasson, Sidgi Syed Anwer
Yemen, Sana'a
University of Science and Technology
Althawab, Faisal M.N.
Yemen, Sana'a
University of Science and Technology
Alaghbari, Sama A.Z.
Yemen, Sana'a
University of Science and Technology
Lindequist, Ulrike
Germany, Greifswald
Universität Greifswald
Statistics
Citations: 237
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1093/ecam/nen004
ISSN:
1741427X
e-ISSN:
17414288
Research Areas
Environmental
Health System And Policy