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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Reduced cord blood immune effector-cell responsiveness mediated by CD4
+
cells induced in utero as a consequence of placental Plasmodium falciparum infection
Journal of Infectious Diseases, Volume 193, No. 1, Year 2006
Notification
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Description
To determine mechanisms of neonatal parasite antigen (Ag)-specific immune suppression associated with placental Plasmodium falciparum infection, we isolated cord blood mononuclear cells (CBMCs) from Gabonese neonates born to mothers with differing histories of P. falciparum infection and performed ex vivo and in vitro studies to evaluate immune regulatory activity. We found increased ex vivo percentages of CD4+CD25hi and CD4 +CD25+CTLA-4+ cells and increased interleukin (IL)-10 responses to parasite Ag in vitro in CBMCs from neonates born to mothers with placental P. falciparum infection at delivery. Depleting CBMCs of CD4 +CD25+ cells before cell culture led to the abrogation of parasite Ag-specific IL-10 responses, to enhanced interferon-γ responses, and to enhanced expression of CD25 on CD8+ T cells and of major histocompatibility complex class I and II on monocytes. These data demonstrate that parasite Ag-specific CD4+ regulatory cells are generated in utero as a consequence of placental P. falciparum infection. © 2005 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
Brustoski, Kim
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Möller, Ulrike
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Kramer, Martin
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Hartgers, Franca C.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Krzych, Urszula
United States, Silver Spring
Walter Reed Army Institute of Research
Luty, A. J.F.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Netherlands, Nijmegen
Radboud University Medical Center
Statistics
Citations: 119
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1086/498578
ISSN:
00221899
Research Areas
Maternal And Child Health