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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Design, synthesis and molecular modeling study of acylated 1,2,4-triazole-3-acetates with potential anti-inflammatory activity
European Journal of Medicinal Chemistry, Volume 44, No. 1, Year 2009
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Description
The present investigation is concerned with the synthesis of different acylated 1,2,4-triazole-3-acetates with the objective of discovering novel and potent anti-inflammatory agents. Structures of the synthesized compounds were elucidated by spectral and elemental analyses. The obtained compounds were evaluated for their anti-inflammatory activites as well as gastric ulcerogenic effects and acute toxicity. Results showed that 1-acylated-5-amino-1,2,4-triazole-3-acetates 3a-e showed higher anti-inflammatory activity than the corresponding 5-acylamino derivatives 4a-e in carageenan-induced rat paw edema test with low gastric ulcerogenicity compared with indomethacin. Furthermore, molecular modeling studies were performed in order to rationalize the obtained biological results. © 2008 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Abdel-Megeed, A.
Egypt, Asyut
Faculty of Pharmacy
Abdel-Rahman, Hamdy M.
Egypt, Asyut
Faculty of Pharmacy
Alkaramany, Gamal Eldin S.
Egypt, Asyut
Faculty of Pharmacy
El Gendy, Mohamed A.M.
Egypt, Asyut
Faculty of Pharmacy
Statistics
Citations: 85
Authors: 4
Affiliations: 1
Identifiers
Doi:
10.1016/j.ejmech.2008.03.017
ISSN:
02235234
e-ISSN:
17683254