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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
High pathogenicity of nipah virus from pteropus lylei fruit bats, Cambodia
Emerging Infectious Diseases, Volume 26, No. 1, Year 2020
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Description
We conducted an in-depth characterization of the Nipah virus (NiV) isolate previously obtained from a Pteropus lylei bat in Cambodia in 2003 (CSUR381). We performed full-genome sequencing and phylogenetic analyses and confirmed CSUR381 is part of the NiV-Malaysia genotype. In vitro studies revealed similar cell permissiveness and replication of CSUR381 (compared with 2 other NiV isolates) in both bat and human cell lines. Sequence alignments indicated conservation of the ephrin-B2 and ephrin-B3 receptor binding sites, the glycosylation site on the G attachment protein, as well as the editing site in phosphoprotein, suggesting production of nonstructural proteins V and W, known to counteract the host innate immunity. In the hamster animal model, CSUR381 induced lethal infections. Altogether, these data suggest that the Cambodia bat-derived NiV isolate has high pathogenic potential and, thus, provide insight for further studies and better risk assessment for future NiV outbreaks in Southeast Asia. © 2020 Centers for Disease Control and Prevention (CDC). All rights reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6924896/bin/19-1284-Techapp-s1.pdf
Authors & Co-Authors
Dumont, Claire
France, Lyon
Université de Lyon
Ferren, Marion
France, Lyon
Université de Lyon
Mathieu, Cyrille
France, Lyon
Université de Lyon
Volchkov, Viktor E.
France, Lyon
Université de Lyon
Georges-Courbot, Marie Claude
France, Lyon
Université de Lyon
France, Paris
Institut Pasteur, Paris
Horvat, Branka
France, Lyon
Université de Lyon
Statistics
Citations: 6
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.3201/eid2601.191284
ISSN:
10806040
Research Areas
Genetics And Genomics
Study Approach
Qualitative