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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Relationship between immunoglobulin isotype response to Plasmodium falciparum blood stage antigens and parasitological indexes as well as splenomegaly in sympatric ethnic groups living in Mali
Acta Tropica, Volume 109, No. 1, Year 2009
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Description
This study aimed to assess correlations between anti-malarial antibody levels and differences in malariometric characteristics, seen between two sympatric ethnic groups, the Fulani and the Dogon, living in Mali. Plasma levels of anti-malarial IgE, IgG, IgG1-4 and total IgE were determined in asymptomatic individuals, of the above mentioned groups, and were correlated to malariometric indexes. Significantly higher levels of anti-malarial IgE, IgG, IgG1-3 and total IgE were detected in the Fulani individuals as compared to the Dogon. No difference in plasma levels of malaria specific IgG4 was noted between the two groups. Within the Fulani, an increase in total IgE levels was associated with the presence of infection. As the IgG4 level increased, the number of clones decreased in the Fulani individuals. A positive correlation between elevated levels of anti-malarial IgG and IgG3 and splenomegaly was noted only within the Fulani group. No other correlations between antibody levels and parasite prevalence, clone numbers or spleen rates were observed in any of the communities. These results suggest that the magnitude of antibody response against Plasmodium falciparum may not be as important as it is believed to be. Instead, the fine specificity or function of the response might be more critical in protection against malaria disease. © 2008 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Vafa, Manijeh
Sweden, Stockholm
Stockholms Universitet
Israelsson, Elisabeth
Sweden, Stockholm
Stockholms Universitet
Maïga, Boubacar B.
Mali, Bamako
University of Bamako
Dolo, Amagana I.
Mali, Bamako
University of Bamako
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako
Troye-Blomberg, Marita
Sweden, Stockholm
Stockholms Universitet
Statistics
Citations: 22
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/j.actatropica.2008.09.001
ISSN:
0001706X
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Mali