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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Haemolytic fungi isolated from sago starch in papua New Guinea
Mycopathologia, Volume 169, No. 2, Year 2010
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Description
Sago haemolytic disease (SHD) is a rare but often fatal illness linked to consumption of stale sago starch in Papua New Guinea. Although the aetiology of SHD remains unknown, mycotoxins are suspected. This study investigated whether fungi isolated from Papua New Guinean sago starch were haemolytic. Filamentous fungi and yeasts from sago starch were grown on sheep blood agar and some on human blood agar. Clear haemolytic activity was demonstrated by 55% of filamentous fungal isolates, but not by yeasts. A semi-quantitative bioassay was developed involving incubation of human erythrocytes with fungal extracts. Extracts of cultures of Penicillium, Aspergillus and Fusarium all caused rapid haemolysis in the bioassay. Partial fractionation of extracts suggested that both polar and non-polar haemolytic components had haemolytic activity in vitro. Further work is warranted to identify these metabolites and determine if they play a role in SHD. © Springer Science+Business Media B.V. 2009.
Authors & Co-Authors
Greenhill, Andrew R.
Australia, Townsville
James Cook University
Guinea
Infection and Immunity
Blaney, Barry J.
Australia, Brisbane
Queensland Department of Agriculture and Fisheries
Shipton, Warren A.
Australia, Townsville
James Cook University
Thailand, Saraburi
Mission College, Thailand
Pue, Aisak
Guinea, Lae
University of Technology
Australia, Brisbane
The University of Queensland
Fletcher, Mary
Australia, Brisbane
Queensland Department of Agriculture and Fisheries
Warner, Jeffrey M.
Australia, Townsville
James Cook University
Statistics
Citations: 7
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1007/s11046-009-9235-3
ISSN:
0301486X
Study Approach
Quantitative
Study Locations
Guinea