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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants
Malaria Journal, Volume 9, No. 1, Article 206, Year 2010
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Description
Objectives. To compare three methods for evaluating treatment adherence in a 7-day controlled treatment period for malaria in children in Rwanda. Methods. Fifty-six children (< 5 years) with malaria were recruited at the University Hospital of Butare, Rwanda. Patients were treated with quinine sulfate, taste-masked, pellets during seven days: three days in hospital (in-patient) followed by a four-day out-patient period. Three methods to evaluate medication adherence among patients were compared: manual pill count of returned tablets, patient self-report and electronic pill-box monitoring. These pill-boxes were equipped with a microchip registering date and time of every opening. Medication adherence was defined as the proportion of prescribed doses taken. The inter-dose intervals were analysed as well. Results. Medication adherence data were available for 54 of the 56 patients. Manual pill count and patient self-report yielded a medication adherence of 100% for the in- and out-patient treatment periods. Based on electronic pill-box monitoring, medication adherence during the seven-day treatment period was 90.5 ± 8.3%. Based on electronic pill-box monitoring inpatient medication adherence (99.3 ± 2.7%) was markedly higher (p < 0.03) than out-patient adherence (82.7 ± 14.7%), showing a clear difference between health workers' and consumers' medication adherence. Conclusion. Health workers' medication adherence was good. However, a significant lower medication adherence was observed for consumers' adherence in the outpatient setting. This was only detected by electronic pill-box monitoring. Therefore, this latter method is more accurate than the two other methods used in this study. © 2010 Twagirumukiza et al; licensee BioMed Central Ltd.
Authors & Co-Authors
Twagirumukiza, Marc
Belgium, Ghent
Heymans Institute of Pharmacology
Rwanda, Kigali
University Hospital
Kayumba, P. C.
Belgium, Ghent
Universiteit Gent
Rwanda
Faculty of Medicine
Kips, Jan G.
Belgium, Ghent
Heymans Institute of Pharmacology
Vrijens, Bernard C.
Belgium, Liege
Université de Liège
Stichele, Robert Vander
Belgium, Ghent
Heymans Institute of Pharmacology
Vervaet, C.
Belgium, Ghent
Universiteit Gent
Remon, Jean Paul
Belgium, Ghent
Universiteit Gent
Van Bortel, M. Luc
Belgium, Ghent
Heymans Institute of Pharmacology
Statistics
Citations: 18
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1186/1475-2875-9-206
e-ISSN:
14752875
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Rwanda