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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
One hundred malaria attacks since birth. A longitudinal study of African children and young adults exposed to high malaria transmission
eClinicalMedicine, Volume 67, Article 102379, Year 2024
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Description
Background: Despite significant progress in malaria control over the past twenty years, malaria remains a leading cause of child morbidity and mortality in Tropical Africa. As most patients do not consult any health facility much uncertainty persists about the true burden of the disease and the range of individual differences in susceptibility to malaria. Methods: Over a 25-years period, from 1990 to 2015, the inhabitants of Dielmo village, Senegal, an area of intense malaria transmission, have been monitored daily for their presence in the village and the occurrence of diseases. In case of fever thick blood films were systematically examined through microscopy for malaria parasites and patients received prompt diagnosis and treatment. Findings: We analysed data collected in 111 children and young adults monitored for at least 10 years (mean 17.3 years, maximum 25 years) enrolled either at birth (95 persons) or during the two first years of life. A total of 11,599 episodes of fever were documented, including 5268 malaria attacks. The maximum number of malaria attacks in a single person was 112. Three other persons suffered one hundred or more malaria attacks during follow-up. The minimum number of malaria attacks in a single person was 11. The mean numbers of malaria attacks in children reaching their 4th, 7th, and 10th birthdays were 23.0, 37.7, and 43.6 attacks since birth, respectively. Sixteen children (14.4%) suffered ten or more malaria attacks each year at ages 1–3 years, and six children (5.4%) each year at age 4–6 years. Interpretation: Long-term close monitoring shows that in highly endemic areas the malaria burden is higher than expected. Susceptibility to the disease may vary up to 10-fold, and for most children childhood is an endless history of malaria fever episodes. No other parasitic, bacterial or viral infection in human populations has such an impact on health. Funding: The Pasteur Institutes of Dakar and Paris, the Institut de Recherche pour le Développement, and the French Ministry of Cooperation provided funding. © 2023 The Author(s)
Authors & Co-Authors
Trape, Jean François
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Diagne, Nafissatou G.
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Diène-Sarr, Fatoumata
Senegal, Dakar
Institut Pasteur de Dakar
Faye, Joseph
Senegal, Dakar
Institut Pasteur de Dakar
Dieye-Ba, Fambaye
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Basséne, Hubert
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Badiane, Abdoulaye
Senegal, Dakar
Institut Pasteur de Dakar
Bouganali, Charles
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Tall, Adama
Senegal, Dakar
Institut Pasteur de Dakar
Ndiaye, Ramatoulaye
Senegal, Dakar
Institut Pasteur de Dakar
Doucouré, Souleymane
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Wotodjo, Amele Nyedzie
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Vigan-Womas, Inès
Senegal, Dakar
Institut Pasteur de Dakar
France, Paris
Institut Pasteur, Paris
Guillotte-Blisnick, Micheline
France, Paris
Institut Pasteur, Paris
Talla, Cheikh
Senegal, Dakar
Institut Pasteur de Dakar
Niang, Makhtar S.
Senegal, Dakar
Institut Pasteur de Dakar
Touré-Baldé, Aïssatou
Senegal, Dakar
Institut Pasteur de Dakar
Perraut, Ronald
Senegal, Dakar
Institut Pasteur de Dakar
France, Paris
Institut Pasteur, Paris
Roussilhon, Christian
Senegal, Dakar
Institut Pasteur de Dakar
France, Paris
Institut Pasteur, Paris
Rogier, Christophe
Senegal, Dakar
Institut Pasteur de Dakar
France, Paris
Primum Vitare
Mercereau-Puijalon, Odile
France, Paris
Institut Pasteur, Paris
Loucoubar, Cheikh
Senegal, Dakar
Institut Pasteur de Dakar
Sokhna, Cheikh Sadibou
Senegal, Dakar
Institut de Recherche Pour le Développement Dakar
Statistics
Authors: 23
Affiliations: 4
Identifiers
Doi:
10.1016/j.eclinm.2023.102379
ISSN:
25895370
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Approach
Quantitative
Study Locations
Senegal