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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression
Immunity, Volume 36, No. 3, Year 2012
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Description
Although Th17 cells are known to promote tissue inflammation and autoimmunity, their role during cancer progression remains elusive. Here, we showed that in vitro Th17 cells generated with the cytokines IL-6 and TGF-β expressed CD39 and CD73 ectonucleotidases, leading to adenosine release and the subsequent suppression of CD4 + and CD8 + T cell effector functions. The IL-6-mediated activation of the transcription factor Stat3 and the TGF-β-driven downregulation of Gfi-1 transcription factor were both essential for the expression of ectonucleotidases during Th17 cell differentiation. Stat3 supported whereas Gfi-1 repressed CD39 and CD73 expression by binding to their promoters. Accordingly, Th17 cells differentiated with IL-1β, IL-6, and IL-23 but without TGF-β did not express ectonucleotidases and were not immunosuppressive. Finally, adoptive transfer of Th17 cells induced by TGF-β and IL-6 promoted tumor growth in a CD39-dependent manner. Thus, ectonucleotidase expression supports the immunosuppressive fate of Th17 cells in cancer. © 2012 Elsevier Inc..
Authors & Co-Authors
Chalmin, Fanny
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Université de Bourgogne
Mignot, Grégoire
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
Bruchard, Mélanie
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Université de Bourgogne
Chevriaux, Angélique
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Centre Georges-françois Leclerc
Végran, Frédérique
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
Hichami, Aziz
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Université de Bourgogne
Ladoire, Sylvain
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Dérangère, Valentin
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Vincent, Julie
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Université de Bourgogne
Masson, David
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Dijon
Université de Bourgogne
Robson, Simon Christopher
United States, Boston
Harvard Medical School
Eberl, Gérard
France, Paris
Institut Pasteur, Paris
France, Paris
Cnrs Centre National de la Recherche Scientifique
Borg, Christophe
France, Paris
Inserm
Ryffel, Bernhard
France, Paris
Cnrs Centre National de la Recherche Scientifique
Apétoh, Lionel
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Centre Georges-françois Leclerc
Rébé, Cédric
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Centre Georges-françois Leclerc
Ghiringhelli, François
France, Dijon
Lipides, Nutrition, Cancer - Lnc
France, Paris
Inserm
France, Dijon
Université de Bourgogne
France, Dijon
Centre Georges-françois Leclerc
Statistics
Citations: 307
Authors: 17
Affiliations: 7
Identifiers
Doi:
10.1016/j.immuni.2011.12.019
ISSN:
10974180
Research Areas
Cancer