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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam
Hepatology, Volume 43, No. 6, Year 2006
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Description
Eight genotypes (A-H) of hepatitis B virus (HBV) have been identified. However, the impact of different genotypes on the clinical course of hepatitis B infection remains controversial. We investigated the frequency and clinical outcome of HBV genotypes and genotype mixtures in HBV-infected patients from Vietnam, Europe, and Africa. In addition, we analyzed the effects of genotype mixtures on alterations in in vitro viral replication. In Asian patients, seven genotypes (A-G) were detected, with A, C, and D predominating. In European and African patients, only genotypes A, C, D, and G were identified. Genotype mixtures were more frequently encountered in African than in Asian (P = .01) and European patients (P = .06). In Asian patients, the predominant genotype mixtures included A/C and C/D, compared to C/D in European and A/D in African patients. Genotype A was more frequent in asymptomatic compared with symptomatic patients (P < .0001). Genotype C was more frequent in patients with hepatocellular carcinoma (HCC; P = .02). Genotype mixtures were more frequently encountered in patients with chronic hepatitis in comparison to patients with acute hepatitis B (P = .015), liver cirrhosis (P = .013), and HCC (P = .002). Viral loads in patients infected with genotype mixtures were significantly higher in comparison to patients with a single genotype (P = .019). Genotype mixtures were also associated with increased in vitro HBV replication. In conclusion, infection with mixtures of HBV genotypes is frequent in Asia, Africa, and Europe. Differences in the replication-phenotype of single genotypes compared to genotype-mixtures suggest that co-infection with different HBV-genotypes is associated with altered pathogenesis and clinical outcome. Copyright © 2006 by the American Association for the Study of Liver Diseases.
Authors & Co-Authors
Toan, Nguyen Linh
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Germany, Tubingen
Eberhard Karls Universität Tübingen
Song, Lehuu
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Viet Nam, Hanoi
Tran Hung Dao Hospital
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Gabon, Lambarene
Unité de Recherche Médicale, Albert Schweitzer Hospital
Duy, Dinh Ng
Viet Nam, Hanoi
Tran Hung Dao Hospital
Binh, Vu Quoc
Viet Nam, Hanoi
Med. Inst.
Koeberlein, Bernd
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Kaiser, Stefan
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Kandolf, Reinhard
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Torresi, Joseph
Australia, Melbourne
University of Melbourne
Bock, C. Thomas
Germany, Tubingen
Universitätsklinikum Und Medizinische Fakultät Tübingen
Statistics
Citations: 125
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1002/hep.21188
ISSN:
02709139
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases