Isolation and characterization of an antimalarial agent of the neem tree azadirachta indica

The isolation and structure elucidation of gedunin [1], the antimalarial agent of Azadirachta indica, are reported. Its lH- and 13C-nmr spectra were assigned by using one- and two-dimensional nmr spectroscopy, especially homonuclear and heteronuclear COSY, nOe difference, and COLOC experiments. © 1989, American Chemical Society. All rights reserved.