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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): Study protocol
BMC Infectious Diseases, Volume 18, No. 1, Article 550, Year 2018
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Description
Background: The Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI) prospectively follows a cohort of healthcare personnel (HCP) in two hospitals in Israel. SHIRI will describe the frequency of influenza virus infections among HCP, identify predictors of vaccine acceptance, examine how repeated influenza vaccination may modify immunogenicity, and evaluate influenza vaccine effectiveness in preventing influenza illness and missed work. Methods: Cohort enrollment began in October, 2016; a second year of the study and a second wave of cohort enrollment began in June 2017. The study will run for at least 3 years and will follow approximately 2000 HCP (who are both employees and members of Clalit Health Services [CHS]) with routine direct patient contact. Eligible HCP are recruited using a stratified sampling strategy. After informed consent, participants complete a brief enrollment survey with questions about occupational responsibilities and knowledge, attitudes, and practices about influenza vaccines. Blood samples are collected at enrollment and at the end of influenza season; HCP who choose to be vaccinated contribute additional blood one month after vaccination. During the influenza season, participants receive twice-weekly short message service (SMS) messages asking them if they have acute respiratory illness or febrile illness (ARFI) symptoms. Ill participants receive follow-up SMS messages to confirm illness symptoms and duration and are asked to self-collect a nasal swab. Information on socio-economic characteristics, current and past medical conditions, medical care utilization and vaccination history is extracted from the CHS database. Information about missed work due to illness is obtained by self-report and from employee records. Respiratory specimens from self-collected nasal swabs are tested for influenza A and B viruses, respiratory syncytial virus, human metapneumovirus, and coronaviruses using validated multiplex quantitative real-time reverse transcription polymerase chain reaction assays. The hemagglutination inhibition assay will be used to detect the presence of neutralizing influenza antibodies in serum. Discussion: SHIRI will expand our knowledge of the burden of respiratory viral infections among HCP and the effectiveness of current and repeated annual influenza vaccination in preventing influenza illness, medical utilization, and missed workdays among HCP who are in direct contact with patients. Trial registration: NCT03331991. Registered on November 6, 2017. © 2018 The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6220521/bin/12879_2018_3444_MOESM1_ESM.docx
Authors & Co-Authors
Katz, Mark A.
Israel, Tel Aviv-yafo
Clalit Health Services
Israel, Beer-sheva
Ben-gurion University of the Negev
United States, Ann Arbor
University of Michigan, Ann Arbor
Greenberg, David P.
Israel, Beer Sheva
Soroka University Medical Center
Shemer-Avni, Yonat
Israel, Beer-sheva
Ben-gurion University of the Negev
Rosenthal, Anat
Israel, Beer-sheva
Ben-gurion University of the Negev
Gur-Arie, Rachel
Israel, Beer-sheva
Ben-gurion University of the Negev
Hertz, Tomer
Israel, Beer-sheva
Ben-gurion University of the Negev
United States, Seattle
Fred Hutchinson Cancer Center
Glatman-Freedman, Aharona
Israel, Jerusalem
Ministry of Health
Israel, Tel Aviv-yafo
Tel Aviv University
Monto, Arnold S.
United States, Ann Arbor
University of Michigan, Ann Arbor
Azziz-Baumgartner, Eduardo
United States, Atlanta
Centers for Disease Control and Prevention
Martín, Emily Toth
United States, Ann Arbor
University of Michigan, Ann Arbor
Levine, Min Z.
United States, Atlanta
Centers for Disease Control and Prevention
Campbell, William
United States, Cambridge
Abt Associates, Inc.
Balicer, Ran D.
Israel, Tel Aviv-yafo
Clalit Health Services
Thompson, Mark G.
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 5
Authors: 14
Affiliations: 11
Identifiers
Doi:
10.1186/s12879-018-3444-7
ISSN:
14712334
Research Areas
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative