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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Radial versus femoral access, bleeding and ischemic events in patients with non-ST-segment elevation acute coronary syndrome managed with an invasive strategy
American Heart Journal, Volume 165, No. 4, Year 2013
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Description
Background Bleeding is a major limitation of antithrombotic therapy among invasively managed non-ST-segment elevation acute coronary syndromes (NSTE-ACS) patients; therefore, we examined the use of radial access and its association with outcomes among NSTE-ACS patients. Methods Clinical characteristics and geographic variation in radial access were examined, as well as its association with bleeding, red blood cell transfusion and ischemic outcomes (96-hour death/myocardial infarction/recurrent ischemic/thrombotic bailout; 30-day death/myocardial infarction; 1-year death) in the EARLY versus delayed, provisional eptifibatide in acute coronary syndromes trial. Results Of 9126 patients, 13.5% underwent radial-access catheterization. Female sex, age, weight, and prior revascularization were inversely associated with radial access, and its use varied widely by country (2%-97%). There were fewer GUSTO severe/moderate bleeds and red blood cell transfusions in the radial access group; however, it was attenuated after adjustment (odds ratio 0.73, 95% confidence intervals [CI] [0.50-1.06], P =.094 and 1.00 [0.71-1.40] P =.991). Ischemic outcomes did not differ by access site. Conclusions In this post hoc analysis of a large clinical trial, there was significant international variation in use of radial access for NSTE-ACS patients undergoing invasive management, and it was preferentially used in those at lower risk for bleeding. Radial approach was not associated with a significant reduction in either bleeding or ischemic outcomes. Further study is needed to determine whether wider application of radial approach to acute coronary syndrome patients at high risk for bleeding improves overall outcomes. © 2013 Mosby, Inc.
Authors & Co-Authors
Klutstein, Marc W.
Israel, Jerusalem
Shaare Zedek Medical Center
Westerhout, Cynthia M.
Canada, Edmonton
University of Alberta
Armstrong, Paul W.
Canada, Edmonton
University of Alberta
Giugliano, Robert P.
United States, Boston
Brigham and Women's Hospital
Lewis, Basil S.
Israel, Haifa
Carmel Medical Center
Gibson, Charles Michael
United States, Boston
Boston University Medical Center
Lutchmedial, Sohrab R.
Canada, St John
Horizon nb
Widimsky, Petr
Czech Republic, Prague
Velke Kunraticke
Steg, Philippe Gabriel
France, Creteil
Université Paris-est Créteil Val de Marne
Dalby, Anthony John
South Africa, Johannesburg
Milpark Hospital
Zeymer, Uwe
Germany, Ludwigshafen
Klinikum Ludwigshafen
van de Werf, Frans J.J.
Belgium, Leuven
Ku Leuven
Harrington, Robert A.
United States, Durham
Duke Clinical Research Institute
Kristin Newby, L.
United States, Durham
Duke Clinical Research Institute
Rao, Sunil V.
United States, Durham
Duke Clinical Research Institute
Statistics
Citations: 19
Authors: 15
Affiliations: 12
Identifiers
Doi:
10.1016/j.ahj.2013.01.009
ISSN:
00028703
e-ISSN:
10976744
Research Areas
Health System And Policy
Study Design
Case-Control Study
Participants Gender
Female