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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Interferon-γ release assays for the diagnosis of latent Mycobacterium tuberculosis infection: A systematic review and meta-analysis
European Respiratory Journal, Volume 37, No. 1, Year 2011
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Description
We conducted a systematic review and meta-analysis to compare the accuracy of the QuantiFERON-TB® Gold In-Tube (QFT-G-IT) and the T-SPOT®.TB assays with the tuberculin skin test (TST) for the diagnosis of latent Mycobacterium tuberculosis infection (LTBI). The Medline, Embase and Cochrane databases were explored for relevant articles in November 2009. Specificities, and negative (NPV) and positive (PPV) predictive values of interferon-γ release assays (IGRAs) and the TST, and the exposure gradient influences on test results among bacille Calmette-Guérin (BCG) vaccinees were evaluated. Specificity of IGRAs varied 98-100%. In immunocompetent adults, NPV for progression to tuberculosis within 2 yrs were 97.8% for T-SPOT®.TB and 99.8% for QFT-G-IT. When test performance of an immunodiagnostic test was not restricted to prior positivity of another test, progression rates to tuberculosis among IGRA-positive individuals followed for 19-24 months varied 8-15%, exceeding those reported for the TST (2-3%). Inmultivariate analyses, the odd ratios for TST positivity following BCG vaccination varied 3-25, whereas IGRA results remained uninfluenced and IGRA positivity was clearly associated with exposure to contagious tuberculosis cases. IGRAs may have a relative advantage over the TST in detecting LTBI and allow the exclusion of M. tuberculosis infection with higher reliability. Copyright©ERS 2011.
Authors & Co-Authors
Diel, Roland
Germany, Hannover
Hannover Medical School
Goletti, Delia
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Ferrara, G.
Italy, Terni
Azienda Ospedaliera S. Maria Di Terni
Bothamley, Graham Henry
United Kingdom, London
Homerton University Hospital Nhs Foundation Trust
Cirillo, D. M.
Italy, Milan
Irccs Ospedale San Raffaele
Kampmann, Beate B.
United Kingdom, London
Imperial College London
Lange, Christoph G.
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Losi, Monica
Italy, Modena
Università Degli Studi Di Modena e Reggio Emilia
Markova, Roumiana
Bulgaria, Sofia
National Center of Infectious and Parasitic Diseases Bulgaria
Migliori, Giovanni Battista
Unknown Affiliation
Rühwald, Morten
Denmark, Hvidovre
Hvidovre Hospital
Wagner, Dirk
Germany, Freiburg Im Breisgau
Universitätsklinikum Freiburg
Zellweger, Jean Pierre
Switzerland, Lausanne
Université de Lausanne Unil
Huitric, Emma
Sweden, Solna
European Centre for Disease Prevention and Control
Sandgren, Andreas
Sweden, Solna
European Centre for Disease Prevention and Control
Manissero, Davide
Sweden, Solna
European Centre for Disease Prevention and Control
Statistics
Citations: 464
Authors: 16
Affiliations: 14
Identifiers
Doi:
10.1183/09031936.00115110
ISSN:
13993003
Research Areas
Infectious Diseases
Study Approach
Systematic review