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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
5,10 methylenetetrahydrofolate reductase polymorphism in black South African women with pre-eclampsia
BJOG: An International Journal of Obstetrics and Gynaecology, Volume 106, No. 11, Year 1999
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Description
The polymorphic C677T mutation in the gene encoding 5,10 methylenetetrahydrofolate reductase has been shown to be a risk factor for pre-eclampsia in Japanese and European women when inherited as a homozygous trait. We attempted to verify these findings in a black African population with a high incidence of pre-eclampsia. No difference in frequency of the T-allele was observed in 105 women with pre-eclampsia, compared with 110 healthy pregnant normotensive women. Only one woman with pre-eclampsia was TT homozygous, suggesting that methylenetetrahydrofolate reductase polymorphism is not an important factor in the pathogenesis of pre-eclampsia in black South African women. © 1999 Blackwell Publishing Ltd.
Authors & Co-Authors
Chikosi, Aggrey B.
South Africa, Congella
Mrc/un Pregnancy Hypertension Research Unit
Moodley, Jagdisea M.
South Africa, Congella
Mrc/un Pregnancy Hypertension Research Unit
Pegoraro, Rosemary J.
South Africa, Congella
University of Natal, Faculty of Medicine
Lanning, Pamela A.
South Africa, Congella
University of Natal, Faculty of Medicine
Rom, Lee
South Africa, Congella
University of Natal, Faculty of Medicine
Statistics
Citations: 36
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1111/j.1471-0528.1999.tb08152.x
ISSN:
14700328
e-ISSN:
14710528
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female