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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection
Infection and Immunity, Volume 82, No. 8, Year 2014
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Description
Malnutrition is thought to contribute to more than one-third of all childhood deaths via increased susceptibility to infection. Malnutrition is a significant risk factor for the development of visceral leishmaniasis, which results from skin inoculation of the intracellular protozoan Leishmania donovani. We previously established a murine model of childhood malnutrition and found that malnutrition decreased the lymph node barrier function and increased the early dissemination of L. donovani. In the present study, we found reduced numbers of resident dendritic cells (conventional and monocyte derived) but not migratory dermal dendritic cells in the skin-draining lymph nodes of L. donovani-infected malnourished mice. Expression of chemokines and their receptors involved in trafficking of dendritic cells and their progenitors to the lymph nodes was dysregulated. C-C chemokine receptor type 2 (CCR2) and its ligands (CCL2 and CCL7) were reduced in the lymph nodes of infected malnourished mice, as were CCR2-bearing monocytes/macrophages and monocyte-derived dendritic cells. However, CCR7 and its ligands (CCL19 and CCL21) were increased in the lymph node and CCR7 was increased in lymph node macrophages and dendritic cells. CCR2-deficient mice recapitulated the profound reduction in the number of resident (but not migratory dermal) dendritic cells in the lymph node but showed no alteration in the expression of CCL19 and CCL21. Collectively, these results suggest that the malnutrition-related reduction in the lymph node barrier to dissemination of L. donovani is related to insufficient numbers of lymph node-resident but not migratory dermal dendritic cells. This is likely driven by the altered activity of the CCR2 and CCR7 chemoattractant pathways. © 2014, American Society for Microbiology.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4136237/bin/supp_82_8_3098__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC4136237/bin/IAI.01778-14_zii999090771so1.pdf
Authors & Co-Authors
Ibrahim, Marwa K.
United States, San Antonio
University of Texas Health Science Center at San Antonio
United States, San Antonio
South Texas Veterans Health Care System
Egypt, Giza
National Research Centre
Barnes, Jeffrey L.
United States, San Antonio
South Texas Veterans Health Care System
United States, San Antonio
University of Texas Health Science Center at San Antonio
Osorio, Elvia Yaneth
United States, Galveston
University of Texas Medical Branch, School of Medicine
Anstead, Gregory M.
United States, San Antonio
South Texas Veterans Health Care System
United States, San Antonio
University of Texas Health Science Center at San Antonio
Jimenez, Fabio
United States, San Antonio
South Texas Veterans Health Care System
United States, San Antonio
University of Texas Health Science Center at San Antonio
Osterholzer, John J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Travi, Bruno Luis
United States, Galveston
University of Texas Medical Branch, School of Medicine
United States, Galveston
The University of Texas Medical Branch at Galveston
Ahuja, Seema S.
United States, San Antonio
South Texas Veterans Health Care System
United States, San Antonio
University of Texas Health Science Center at San Antonio
White, A. Clinton
United States, Galveston
University of Texas Medical Branch, School of Medicine
Melby, Peter C.
United States, San Antonio
University of Texas Health Science Center at San Antonio
United States, Galveston
University of Texas Medical Branch, School of Medicine
United States, Galveston
The University of Texas Medical Branch at Galveston
Statistics
Citations: 17
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1128/IAI.01778-14
ISSN:
00199567
e-ISSN:
10985522
Research Areas
Food Security
Maternal And Child Health