Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Evidence of a decline in transmitted HIV-1 drug resistance in the United Kingdom
AIDS, Volume 21, No. 8, Year 2007
Notification
URL copied to clipboard!
Description
OBJECTIVE: To examine recent trends in transmitted drug resistance (TDR) in the United Kingdom. METHODS: Analysis of results of genotypic resistance tests reported to the UK HIV Drug Resistance Database, which includes virtually all tests conducted as part of routine clinical care nationally. Resistance was based on major mutations as defined in the 2005 International AIDS Society-USA guidelines. Analysis was restricted to persons who were antiretroviral treatment-naive at the time of sampling, and a test defined as relating to recent infection if the patient was co-enrolled in the UK Register of HIV Seroconverters and the sample taken within 18 months of a negative HIV antibody test. RESULTS: A total of 4454 samples from treatment-naive patients between 1996 and 2004 were analysed, including 316 from patients recently infected at the time of the resistance test. After an initial rise, TDR declined from a peak of around 14% in 2001-2002 to around 8% by the end of 2004 (Ptrend < 0.001), largely driven by a decrease in nucleos(t)ide reverse transcriptase inhibitor (NRTI) mutations. Non-NRTI resistance has become increasingly important in relative terms and is now as common as NRTI resistance. Among patients with recent infection, an almost identical pattern was observed but shifted approximately 2 years earlier. A change in the distribution of viral subtypes did not explain these temporal trends. CONCLUSIONS: This is the first clear evidence of a decrease in TDR at national level. The wider use of regimens that suppress viral concentration to below infectious levels is one of several plausible explanations for this finding. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Burns, Sheila M.
United Kingdom, Edinburgh
Royal Infirmary of Edinburgh
Cane, Patricia A.
United Kingdom, London
Public Health England
Chrystie, Ian L.
United Kingdom, London
Guy's and st Thomas' Nhs Foundation Trust
Churchill, Duncan R.
United Kingdom, Worthing
University Hospitals Sussex Nhs Foundation Trust
Delpech, Valerie C.
United Kingdom, London
Public Health England
Morris, Lynn G.
United Kingdom, London
Public Health England
United Kingdom, London
Ucl Medical School
Dunn, David T.
United Kingdom, London
Mrc Clinical Trials Unit
Fearnhill, Esther
United Kingdom, London
Mrc Clinical Trials Unit
Porter, Kholoud
United Kingdom, London
Mrc Clinical Trials Unit
Easterbrook, Philippa Jane
United Kingdom, London
King's College Hospital
Geretti, Anna María
United Kingdom, London
Royal Free London Nhs Foundation Trust
Gifford, Robert J.M.
United Kingdom, London
Ucl Medical School
Kellam, P.
United Kingdom, London
Ucl Medical School
Phillips, Andrew N.
United Kingdom, London
Ucl Medical School
Sabin, Caroline Anne
United Kingdom, London
Ucl Medical School
Goldberg, David J.
United Kingdom, Glasgow
Health Protection Scotland
Gompels, Mark M.
United Kingdom, Bristol
Southmead Hospital Bristol
Hale, Antony D.
United Kingdom, Leeds
Leeds Teaching Hospitals Nhs Trust
Kaye, Steve
United Kingdom, London
St Mary's Hospital
Leigh Brown, Andrew J.
United Kingdom, Edinburgh
The University of Edinburgh
Orkin, Chloë M.
United Kingdom, London
St Bartholomew's Hospital
Pozniak, Anton Louis
United Kingdom, London
Chelsea and Westminster Hospital
Smit, Erasmus J.
United Kingdom, London
Public Health England
Tilston, Peter
United Kingdom, Manchester
Manchester Royal Infirmary
Williams, Ian G.
United Kingdom, London
University College London
Statistics
Citations: 67
Authors: 25
Affiliations: 18
Identifiers
Doi:
10.1097/QAD.0b013e3280b07761
ISSN:
02699370
Research Areas
Health System And Policy
Infectious Diseases