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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Neonatal tetanus despite protective serum antitoxin concentration
FEMS Microbiology Letters, Volume 76, No. 3, Year 1991
Notification
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Description
Using the ELISA technique to estimate serum antibodies against tetanus toxin, seven neonates with clinical tetanus were found to have antibody levels 4-13 times higher than the presumed minimum protective level of 0.01 IU/ml. All but one of their mothers had been vaccinated with tetanus toxoid in pregnancy. In two other neonates, whose mothers had received multiple booster doses of toxoid during pregnancy, the anti-toxin concentrations were 100- and 400-times the presumed protective level. Therefore the toxin dose may overwhelm the pre-existing anti-toxin level and produce disease. Furthermore, multiple booster injections of tetanus toxoid may not only enhance serum anti-toxin titres, but could also lead to an ineffective immune response. © 1991.
Authors & Co-Authors
Maselle, Samuel Y.M.
Norway, Bergen
Universitetet I Bergen
Matre, Roald
Norway, Bergen
Universitetet I Bergen
Mbise, Roger L.
Tanzania, Dar es Salaam
Muhimbili Medical Centre
Hofstad, T.
Norway, Bergen
Universitetet I Bergen
Statistics
Citations: 4
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1016/0378-1097(91)90054-E
ISSN:
03781097
e-ISSN:
15746968
Research Areas
Maternal And Child Health
Sexual And Reproductive Health