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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Mycobacterium africanum elicits an attenuated t cell response to early secreted antigenic target, 6 kDa, in patients with tuberculosis and their household contacts
Journal of Infectious Diseases, Volume 193, No. 9, Year 2006
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Description
Background. Mycobacterium africanum, a member of the M. tuberculosis complex that is infrequently found outside of western Africa, is the cause of up to half of the tuberculosis cases there. Methods. We genotyped mycobacterial isolates obtained from a study of patients with tuberculosis and their household contacts and compared T cell responses and tuberculin skin test results by infecting genotype. Results. The T cell response to early secreted antigenic target, 6 kDa (ESAT-6), was attenuated in patients with tuberculosis (odds ratio [OR], 0.41 [95% confidence interval {CI}, 0.19-0.89]; P = .024) and household contacts (OR, 0.56 [95% CI, 0.38-0.83]; P = .004) infected with M. africanum, compared with the response in those infected with M. tuberculosis. In these same groups, responses to culture filtrate protein, 10 kDa (CFP-10), were nonsignificantly attenuated (P = .22 and P= .16, respectively), as were tuberculin skin test results (P = .30 and P = .46, respectively). Sequencing of region of difference 1 of M. africanum revealed that Rv3879c is a pseudogene in M. africanum; however, this finding does not provide an obvious mechanism for the attenuated ESAT-6 response. Conclusions. This is the first evidence, to our knowledge, that strain differences affect interferon-γ-based T cell responses. Our findings highlight the need to test new diagnostic candidates against different strains of mycobacteria. Integrating additional immunologic and genomic comparisons of M. tuberculosis and M. africanum into further studies may provide fundamental insights into the interactions between humans and mycobacteria. © 2006 by the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
De-Jong, Bouke Catherine
Gambia, Banjul
Medical Research Council Laboratories Gambia
United States, Stanford
Stanford University School of Medicine
Hill, Philip C.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Brookes, Roger H.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Gagneux, Sébastien P.
United States, Stanford
Stanford University School of Medicine
United States, Seattle
Institute for Systems Biology
Jeffries, David J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Otu, Jacob Kweku
Gambia, Banjul
Medical Research Council Laboratories Gambia
Donkor, Simon A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
FOX, A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
McAdam, Keith P.W.J.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Small, Peter M.
United States, Seattle
Institute for Systems Biology
Adegbola, Richard A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Citations: 86
Authors: 11
Affiliations: 3
Identifiers
Doi:
10.1086/502977
ISSN:
00221899
Research Areas
Genetics And Genomics
Study Design
Case-Control Study