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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Multifocal small bowel stromal tumours presenting with peritonitis in an HIV positive patient
International Journal of Surgery Case Reports, Volume 5, No. 5, Year 2014
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Description
Introduction The most common mesenchymal tumour of the gastrointestinal tract is stromal tumours (GISTs). Symptomatic GISTs can present with complications such as haemorrhage, obstruction and perforation. Complete surgical resection with negative margins is the mainstay of treatment but may be imprudent on emergent occasion. Tyrosine-kinase inhibitors (TKIs) have been revolutionary in the treatment of GISTs and have resulted in improved outcomes. PRESENTATION OF CASE A 41 year old HIV positive male presented with an acute history of abdominal pain and obstructive symptoms. Clinical examination revealed sepsis and peritonitis. One of the several small bowel tumours discovered at exploratory laparotomy was necrotic and perforated. The perforated tumour alone was resected and a small bowel internal hernia reduced. The patient made an uneventful recovery and will be considered for TKI therapy with a view to later re-operation. DISCUSSION GISTs very rarely perforate. The pathophysiology of stromal tumour necrosis is poorly understood. Multifocality and small bowel location are poor prognosticators and may occur in the setting of familial GISTs, specific syndromes and sporadic cases. There is no established association between HIV and GISTs. CONCLUSION Perforation occurs infrequently in ≤8% of symptomatic cases and poses increased risk of local recurrence. The surgical management of perforation takes precedence in an emergency. The surgeon must however take cognisance of the adherence to ideal oncologic principles where feasible. TKI therapy is invaluable if a re-exploration is to be later considered. © 2014 The Author.
Authors & Co-Authors
Mansoor, Ebrahim
South Africa, Durban
The Nelson R. Mandela Medical School
Statistics
Citations: 6
Authors: 1
Affiliations: 1
Identifiers
Doi:
10.1016/j.ijscr.2014.03.005
e-ISSN:
22102612
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Study Design
Exploratory Study
Participants Gender
Male