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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Identification of antibacterial and antifungal pharmacophore sites for potent bacteria and fungi inhibition: Indolenyl sulfonamide derivatives
European Journal of Medicinal Chemistry, Volume 45, No. 3, Year 2010
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Description
Synthesis of seven new indolenyl sulfonamides, have been prepared by the condensation reaction of indole-3-carboxaldehyde with different sulfonamides such as, sulphanilamide, sulfaguanidine, sulfathiazole, sulfamethoxazole, sulfisoxazole, sulfadiazine and sulfamethazine. These synthesized compounds have been used as potential ligands for complexation with some selective divalent transition metal ions (cobalt, copper, nickel & zinc). Structure of the synthesized ligands has been deduced from their physical, analytical (elemental analyses) and spectral (IR, 1H NMR and 13C NMR & UV-vis) data. All the compounds have also been assayed for their in vitro antibacterial and antifungal activities examining six species of pathogenic bacteria (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and six of fungi (Trichophyton longifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium soloni and Candida glabrata). Antibacterial and antifungal results showed that all the compounds showed significant antibacterial activity whereas most of the compounds displayed good antifungal activity. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina. Crown Copyright © 2009.
Authors & Co-Authors
Chohan, Zahid Hussain
Pakistan, Multan
Bahauddin Zakariya University
Youssoufi, Moulay Hfid
Morocco, Oujda
Université Mohammed Premier Oujda
Jarrahpour, Aliasghar
Iran, Shiraz
Shiraz University
Ben Hadda, Taibi
Morocco, Oujda
Université Mohammed Premier Oujda
Statistics
Citations: 168
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejmech.2009.11.029
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Infectious Diseases