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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Infective Endocarditis Caused by Staphylococcus aureus After Transcatheter Aortic Valve Replacement
Canadian Journal of Cardiology, Volume 38, No. 1, Year 2022
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Description
Background: Staphylococcus aureus (SA) has been extensively studied as causative microorganism of surgical prosthetic-valve infective endocarditis (IE). However, scarce evidence exists on SA IE after transcatheter aortic valve replacement (TAVR). Methods: Data were obtained from the Infectious Endocarditis After TAVR International Registry, including patients with definite IE after TAVR from 59 centres in 11 countries. Patients were divided into 2 groups according to microbiologic etiology: non-SA IE vs SA IE. Results: SA IE was identified in 141 patients out of 573 (24.6%), methicillin-sensitive SA in most cases (115/141, 81.6%). Self-expanding valves were more common than balloon-expandable valves in patients presenting with early SA IE. Major bleeding and sepsis complicating TAVR, neurologic symptoms or systemic embolism at admission, and IE with cardiac device involvement (other than the TAVR prosthesis) were associated with SA IE (P < 0.05 for all). Among patients with IE after TAVR, the likelihood of SA IE increased from 19% in the absence of those risk factors to 84.6% if ≥ 3 risk factors were present. In-hospital (47.8% vs 26.9%; P < 0.001) and 2-year (71.5% vs 49.6%; P < 0.001) mortality rates were higher among patients with SA IE vs non-SA IE. Surgery at the time of index SA IE episode was associated with lower mortality at follow-up compared with medical therapy alone (adjusted hazard ratio 0.46, 95% CI 0.22-0.96; P = 0.038). Conclusions: SA IE represented approximately 25% of IE cases after TAVR and was associated with very high in-hospital and late mortality. The presence of some features determined a higher likelihood of SA IE and could help to orientate early antibiotic regimen selection. Surgery at index SA IE was associated with improved outcomes, and its role should be evaluated in future studies. © 2021 Canadian Cardiovascular Society
Authors & Co-Authors
Abdel-Wahab, Mohamed Kader
Germany, Leipzig
Herzzentrum Leipzig
Durand, Éric
France, Caen
Normandie Université
Ihlemann, Nikolaj
Denmark, Copenhagen
Rigshospitalet
Pellegrini, Costanza
Germany, Munich
Technische Universität München
Giannini, F.
Italy, Milan
Irccs Ospedale San Raffaele
Wojakowski, Wojciech
Poland, Katowice
Slaski Uniwersytet Medyczny w Katowicach
Landt, Martin
Unknown Affiliation
Sinning, Jan Malte
Unknown Affiliation
Cheema, Asim N.
Canada, Toronto
Saint Michael's Hospital University of Toronto
United States, Richmond
Newmarket Corporation
Nombela-Franco, Luís
Spain, Madrid
Hospital Clínico San Carlos
Campelo-Parada, Francisco
France, Toulouse
Hôpital Rangueil
Testa, Luca
Italy, San Donato Milanese
Gruppo Ospedaliero San Donato
Tchétché, Didier
France, Toulouse
Clinique Pasteur
Bartorelli, Antonio L.
Italy, Milan
Irccs Centro Cardiologico Monzino
Kapadia, Samir R.
United States, Cleveland
Cleveland Clinic Foundation
Stortecky, Stefan
Switzerland, Bern
University of Bern
Amat, Ignacio J.
Spain, Madrid
Centro de Investigación en Red en Enfermedades Cardiovasculares
Wijeysundera, Harindra Channa
Canada, Toronto
Sunnybrook Health Sciences Centre
Lerakis, Stamatios
United States, Atlanta
Emory University School of Medicine
United States, New York
The Mount Sinai Hospital
Kappert, Utz W.
Germany, Dresden
Herzzentrum Dresden Universitätsklinik
Barbanti, Marco
Italy, Catania
Azienda Ospedaliero Universitaria Policlinico G.rodolico - San Marco
Fiorina, Claudia
Italy, Brescia
Spedali Civili Di Brescia
Miceli, Antonio
Italy, Milan
Istituto Clinico Sant’ambrogio
Ireland, Galway
University Hospital Galway
Kodali, Susheel K.
United States, New York
Columbia University Irving Medical Center
Ribeiro, Henrique B.
Brazil, Sao Paulo
Universidade de São Paulo
Brazil, Sao Paulo
Hospital Samaritano
Mangione, José Armando
Brazil, Paraiso
Beneficenca Portuguesa Hospital Sao Paulo
Abizaid, Alexandre A.C.
Brazil, Sao Paulo
Universidade de São Paulo
Alfonso, Fernando
Spain, Madrid
Hospital Universitario de la Princesa
Eltchaninoff, Helénè
France, Caen
Normandie Université
Søndergaard, Lars
Denmark, Copenhagen
Rigshospitalet
Latib, Azeem M.
Italy, Milan
Irccs Ospedale San Raffaele
United States, New York
Montefiore Medical Center
Le Breton, Hervé
France, Rennes
Centre Hospitalier Universitaire de Rennes
Servoz, Clément
France, Toulouse
Hôpital Rangueil
Webb, John G.
Canada, Vancouver
St. Paul's Hospital, Vancouver
Sponga, Sandro
Italy, Udine
Policlinico Universitario, Udine
Makkar, Rajendra R.
United States, Los Angeles
Cedars-sinai Medical Center
Kini, Annapoorna S.
United States, New York
The Mount Sinai Hospital
Boukhris, Marouane
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Holzhey, David Michael
Germany, Leipzig
Herzzentrum Leipzig
Rodés-Cabau, Josep
Canada, Quebec
Université Laval
Spain, Barcelona
Hospital Clinic Barcelona
Statistics
Citations: 6
Authors: 40
Affiliations: 54
Identifiers
Doi:
10.1016/j.cjca.2021.10.004
ISSN:
0828282X
Research Areas
Environmental
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study