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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Monitoring detrusor oxygenation and hemodynamics noninvasively during dysfunctional voiding
Advances in Urology, Article 676303, Year 2012
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Description
The current literature indicates that lower urinary tract symptoms (LUTSs) related to benign prostatic hyperplasia (BPH) have a heterogeneous pathophysiology. Pressure flow studies (UDSs) remain the gold standard evaluation methodology for such patients. However, as the function of the detrusor muscle depends on its vasculature and perfusion, the underlying causes of LUTS likely include abnormalities of detrusor oxygenation and hemodynamics, and available treatment options include agents thought to act on the detrusor smooth muscle and/or vasculature. Hence, near infrared spectroscopy (NIRS), an established optical methodology for monitoring changes in tissue oxygenation and hemodynamics, has relevance as a means of expanding knowledge related to the pathophysiology of BPH and potential treatment options. This methodological report describes how to conduct simultaneous NIRS monitoring of detrusor oxygenation and hemodynamics during UDS, outlines the clinical implications and practical applications of NIRS, explains the principles of physiologic interpretation of NIRS voiding data, and proposes an exploratory hypothesis that the pathophysiological causes underlying LUTS include detrusor dysfunction due to an abnormal hemodynamic response or the onset of oxygen debt during voiding. © 2012 Andrew J. Macnab et al.
Authors & Co-Authors
Macnab, A. J.
Canada, Vancouver
Ubc Hospital
South Africa, Stellenbosch
Stellenbosch Institute for Advanced Study
Stothers, Lynn S.
Canada, Vancouver
Ubc Hospital
Shadgan, Babak
Canada, Vancouver
Ubc Hospital
Statistics
Citations: 18
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1155/2012/676303
ISSN:
16876369
e-ISSN:
16876377
Research Areas
Cancer
Study Design
Exploratory Study