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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Investigating lung remodeling in Modul8
®
-treated BALB/c asthmatic animals
Micron, Volume 40, No. 8, Year 2009
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Description
Animal models of bronchial hyperresponsiveness have been successfully used to investigate the pathophysiology of asthma. When mice are sensitized and challenged with an allergen, such as OVA, they experience symptoms and processes similar to that of humans, and are therefore widely used as asthmatic animal models. In the current study the BALB/c murine asthmatic animal model was used to investigate the histological and ultrastructural changes that occur in the lungs of asthmatic animals that received no treatment, compared to two groups of asthmatic animals that were treated with a homeopathic immunodulator Modul8® and hydrocortisone as positive control, respectively. Eosinophil counts in the bronchial lavage of the animals were also analyzed, since it is known that eosinophil counts are increased in the bronchial lavage in asthma. Results indicated that eosinophil counts were elevated in asthmatic animals compared to the controls, but were found to be significantly decreased in the treatment groups. Also, in the asthmatic, untreated animals, histological and ultrastructural changes, typically associated with the inflammatory process were found. Both treatment groups compared well to that of the control animals, indicating that the homeopathic product might be successfully used in the treatment of asthma. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Oberholzer, Hester Magdalena
South Africa, Pretoria
Faculty of Health Sciences
Pretorius, Etheresia
South Africa, Pretoria
Faculty of Health Sciences
Statistics
Citations: 6
Authors: 2
Affiliations: 1
Identifiers
Doi:
10.1016/j.micron.2009.07.008
ISSN:
09684328