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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Relation between left ventricular geometry and transmural dispersion of repolarization
American Journal of Cardiology, Volume 96, No. 7, Year 2005
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Description
Studies have shown an association between left ventricular (LV) geometry and complex ventricular ectopic activity. Increased transmural dispersion of repolarization (TDR), which correlates to the interval from the peak to the end of the T wave (Tpe) on the surface electrocardiogram, is linked to ventricular tachyarrhythmias. The relation between LV geometry and TDR is unknown. The mean Tpe interval, measured from leads V1 to V3 of the surface electrocardiogram, was assessed in 300 patients (50% men) who had normal LV systolic function and QRS duration and were categorized into 3 equal groups, which were matched by age and gender, according to echocardiographically determined LV geometry (normal structure, concentric remodeling, and LV hypertrophy). The Tpe interval was corrected for the QT interval using Tpe/QTc and was compared among the 3 groups. Compared with those who had normal LV structure, the Tpe interval was significantly prolonged in those who had LV hypertrophy and significantly shortened in those who had concentric remodeling (p = <0.0001 for the 2 comparisons). Correcting for the QT interval using Tpe/QTc yielded similar results. Thus, TDR was increased in patients who had LV hypertrophy but decreased in concentric remodeling compared with those who had normal cardiac structure. Although LV hypertrophy represents a maladaptive geometric process that results in an unfavorable electrical substrate, concentric remodeling may represent a structural adaptation that has a more favorable electrical milieu. © 2005 Elsevier Inc. All rights reserved.
Authors & Co-Authors
Saba, Magdi M.
United States, New Orleans
Ochsner Health
Egypt, Giza
Cairo University
Arain, Salman A.
United States, New Orleans
Ochsner Health
Lavie, Carl J.
United States, New Orleans
Ochsner Health
Abi-Samra, Freddy M.
United States, New Orleans
Ochsner Health
Ibrahim, Salma S.
United States, College Park
University of Maryland, College Park
Ventura, Hector O.
United States, New Orleans
Ochsner Health
Milani, Richard V.
United States, New Orleans
Ochsner Health
Statistics
Citations: 21
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1016/j.amjcard.2005.05.053
ISSN:
00029149
Research Areas
Noncommunicable Diseases
Participants Gender
Male