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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Surprisingly high prevalence of subtype C and specific HIV-1 subtype/CRF distribution in men having sex with men in Senegal
Journal of Acquired Immune Deficiency Syndromes, Volume 52, No. 2, Year 2009
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Description
BACKGROUND: Recent reports showed the high vulnerability for HIV infection of men who have sex with men (MSM) in Africa. Here, we report the HIV-1 variants that circulate among MSM in Senegal. METHODS: HIV-1 subtype/circulating recombinant form (CRF) was determined in an 1800-base pair fragment of pol for 70 HIV-1-positive samples from MSM. Phylogenetic trees were constructed using the neighbor-joining method with CLUSTALX. Similarity and bootstrap plots were then done for recombination analysis. The maximum likelihood approach was used for the identification of transmission clusters. RESULTS: Sixty-seven samples (95%) were from Senegalese MSM, 90% unmarried with a median age of 30 years. Fifty-five MSM had regular male partners, but 39 of 70 had also a regular female partner. The overall subtype/CRF distribution was as follows: 28 C (40%), 17 CRF02-AG (24.3%), 13 B (18.6%), 6 G (8.6%), 3 CRF09-cpx (4.3%), and 3 (4.3%) unique recombinants. In addition, 47 sequences (67.15%) were segregated into 15 transmission clusters. CONCLUSIONS: These variants circulate also among the general population or female sex workers, but the proportions are significantly different. Despite the massive stigma, the majority (80%) of MSM recognized having sex with women and could serve as a bridge for intermixing of HIV-1 variants between high-risk men and low-risk women. Copyright © 2009 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Diop-Ndiaye, Halimatou
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Touré-Kâne, Coumba
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Vidal, Nicole
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Niama, Fabien Roch
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Niang-Diallo, Pape Amadou
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Diéye, Tandakha Ndiaye D.
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Gaye-Diallo, Aïssatou
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Wade, Abdoulaye S.
Senegal, Dakar
Division de Lutte Contre le Sida/ist
Peeters, Martine F.
France, Montpellier
Recherches Translationnelles Sur le Vih et Les Maladies Infectieuses
Mboup, Souleymane
Senegal, Dakar
Centre Hospitalier Universitaire Aristide le Dantec de Dakar
Statistics
Citations: 36
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1097/QAI.0b013e3181af70a4
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Senegal
Participants Gender
Male
Female