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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response
Vaccine, Volume 27, No. 40, Year 2009
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Description
Background: In most tuberculosis (TB) endemic countries, bacillus Calmette-Guérin (BCG) is usually given around birth to prevent severe TB in infants. The neonatal immune system is immature. Our hypothesis was that delaying BCG vaccination from birth to 10 weeks of age would enhance the vaccine-induced immune response. Methods: In a randomized clinical trial, BCG was administered intradermally either at birth (n = 25) or at 10 weeks of age (n = 21). Ten weeks after vaccination, and at 1 year of age, vaccine-specific CD4 and CD8 T cell responses were measured with a whole blood intracellular cytokine assay. Results: Infants who received delayed BCG vaccination demonstrated higher frequencies of BCG-specific CD4 T cells, particularly polyfunctional T cells co-expressing IFN-γ, TNF-α and IL-2, and most strikingly at 1 year of age. Conclusions: Delaying BCG vaccination from birth to 10 weeks of age enhances the quantitative and qualitative BCG-specific T cell response, when measured at 1 year of age. © 2009 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
M Kagina, Benjamin Mugo N.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Abel, Brian
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Bowmaker, Mark
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Scriba, Thomas J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Gelderbloem, Sebastian J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Smit, Erica
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Erasmus, Mzwandile
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Nene, Nonhlanhla F.
South Africa, Stellenbosch
Stellenbosch University
Walzl, Gerhard
South Africa, Stellenbosch
Stellenbosch University
Black, Gillian Frances
South Africa, Stellenbosch
Stellenbosch University
Hussey, Greg Dudley
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Hesseling, Anneke Catharina
South Africa, Stellenbosch
Stellenbosch University
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Statistics
Citations: 111
Authors: 13
Affiliations: 2
Identifiers
Doi:
10.1016/j.vaccine.2009.06.103
ISSN:
0264410X
Research Areas
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Study Approach
Qualitative
Quantitative