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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Threshold survey evaluating transmitted HIV drug resistance among public antenatal clinic clients in Addis Ababa, Ethiopia
Antiviral Therapy, Volume 13, No. SUPPL. 2, Year 2008
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Description
Background: Expanded access to HIV therapy in the developing world raises serious concerns regarding the potential emergence and transmission of drug-resistant HIV strains. Although HIV drug resistance surveillance is recommended to track transmitted HIV drug resistance among newly infected individuals, the financial constraints in resource-limited countries prohibit such surveillance on a regular basis. The World Health Organization (WHO) recently introduced guidelines to address this issue. Methods: A survey was conducted in Ethiopia following the WHO guidelines to assess transmitted HIV drug resistance among recently HIV-infected individuals in Addis Ababa. Antiretroviral drug usage started 3 years earlier than commencement of the current expanded access to antiretroviral therapy in Ethiopia. Results: Of 75 eligible samples, 39 (52%) were successfully sequenced and genotyped in the protease and reverse transcriptase region, using both the ViroSeq® and TrueGene® genotyping systems, and analysed for drug resistance mutations using an algorithm from the Stanford HIV Reverse Transcriptase and Protease Database. The analysis revealed that transmitted HIV drug resistance in Addis Ababa is below the 5% threshold level for all three classes of antiretrovirals. Conclusions: The current first-line antiretroviral therapy strategy can be used with confidence in Ethiopia at this time; however, Ethiopia should conduct similar periodic surveys that include the capitals of Ethiopia's larger regional states to ensure early detection of any changes in the country's HIV drug resistance trend. © 2008 International Medical Press.
Authors & Co-Authors
Abegaz, Woldaregay Erku
Ethiopia, Addis Ababa
Addis Ababa University
Grossman, Zehava
Israel, Jerusalem
Ministry of Health
Wolday, Dawit
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Ram, Daniela
Israel, Jerusalem
Ministry of Health
Kaplan, Jonathan E.
United States, Atlanta
Centers for Disease Control and Prevention
Sibide, Kassim
United States, Atlanta
Centers for Disease Control and Prevention
Wuhib, Tadesse
United States, Atlanta
Centers for Disease Control and Prevention
Ismael, Shabbir
United States, Atlanta
Centers for Disease Control and Prevention
N’kengasong, John Nkemngong
United States, Atlanta
Centers for Disease Control and Prevention
Mekonen, Teferi
United States, Atlanta
Centers for Disease Control and Prevention
Berhanu, Hiwot
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Messele, Tsehaynesh
Ethiopia, Addis Ababa
Ethiopian Public Health Institute
Lulseged, Sileshi
United States, Atlanta
Centers for Disease Control and Prevention
Maayan, Sholomo L.
Israel, Jerusalem
Hadassah University Medical Centre
Mengistu, Yohannes
Ethiopia, Addis Ababa
Addis Ababa University
United States, Atlanta
Centers for Disease Control and Prevention
Statistics
Citations: 15
Authors: 15
Affiliations: 5
Identifiers
ISSN:
13596535
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Ethiopia