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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Fructose-Asparagine Is a Primary Nutrient during Growth of Salmonella in the Inflamed Intestine
PLoS Pathogens, Volume 10, No. 6, Article e1004209, Year 2014
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Description
Salmonella enterica serovar Typhimurium (Salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. We have determined that Salmonella encodes an uptake and utilization pathway specific for a novel nutrient, fructose-asparagine (F-Asn), which is essential for Salmonella fitness in the inflamed intestine (modeled using germ-free, streptomycin-treated, ex-germ-free with human microbiota, and IL10-/- mice). The locus encoding F-Asn utilization, fra, provides an advantage only if Salmonella can initiate inflammation and use tetrathionate as a terminal electron acceptor for anaerobic respiration (the fra phenotype is lost in Salmonella SPI1- SPI2- or ttrA mutants, respectively). The severe fitness defect of a Salmonella fra mutant suggests that F-Asn is the primary nutrient utilized by Salmonella in the inflamed intestine and that this system provides a valuable target for novel therapies. © 2014 Ali et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC4072780/bin/ppat.1004209.s001.xlsx
Authors & Co-Authors
Ali, Mohamed Medhat
United States, Columbus
The Ohio State University
Egypt, Mansoura
Faculty of Medicine
Newsom, David L.
United States, Columbus
Research Institute at Nationwide Childrens Hospital
Gonzalez, Juan F.
United States, Columbus
The Ohio State University
Sabag-Daigle, Anice
United States, Columbus
The Ohio State University
Stahl, Christopher
United States, Columbus
The Ohio State University
Steidley, Brandi
United States, Columbus
The Ohio State University
Dubena, Judith
United States, Columbus
The Ohio State University
Dyszel, Jessica L.
United States, Columbus
The Ohio State University
Smith, Jenee N.
United States, Columbus
The Ohio State University
Dieye, Yakhya
United States, Columbus
The Ohio State University
Arsenescu, Razvan I.
United States, Columbus
The Ohio State University
Boyaka, Prosper N.
United States, Columbus
The Ohio State University
Krakowka, Steven G.
United States, Columbus
The Ohio State University
Romeo, Tony
United States, Gainesville
University of Florida
Behrman, Edward J.
United States, Columbus
The Ohio State University
White, Peter
United States, Columbus
Research Institute at Nationwide Childrens Hospital
Ahmer, Brian M.M.
United States, Columbus
The Ohio State University
Statistics
Citations: 60
Authors: 17
Affiliations: 4
Identifiers
Doi:
10.1371/journal.ppat.1004209
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Food Security
Infectious Diseases