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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Comparison of silver-impregnated with standard multi-lumen central venous catheters in critically ill patients
Critical Care Medicine, Volume 35, No. 4, Year 2007
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Description
OBJECTIVES: To evaluate a new silver-impregnated multi-lumen central venous catheter for reducing catheter-related colonization in intensive care patients. DESIGN: Multicenter, prospective, randomized, controlled clinical study. SETTING: Ten adult intensive care units (multidisciplinary, medical and surgical, university and nonuniversity hospitals) in eight institutions. PATIENTS: A total of 577 patients who required 617 multi-lumen central venous catheters between November 2002 and April 2004 were studied. INTERVENTIONS: Intensive care adult patients requiring multi-lumen central venous catheters expected to remain in place for ≥3 days were randomly assigned to undergo insertion of silver-impregnated catheters (silver group) or standard catheters (standard group). Catheter colonization was defined as the growth of ≥1,000 colony-forming units in culture of the intravascular tip of the catheter by the vortexing method. Diagnosis of catheter-related infection was performed by an independent and blinded expert committee. RESULTS: A total of 320 catheters were studied in the silver group and 297 in the standard group. Characteristics of the patients, insertion site, duration of catheterization (median, 11 vs. 10 days), and other risk factors for infection were similar in the two groups. Colonization of the catheter occurred in 47 (14.7%) vs. 36 (12.1%) catheters in the silver and the standard groups (p = .35), for an incidence of 11.2 and 9.4 per 1,000 catheter days, respectively. Catheter-related bloodstream infection was recorded in eight (2.5%) vs. eight (2.7%) catheters in the silver and the standard groups (p = .88), for an incidence of 1.9 and 2.1 per 1,000 catheter days, respectively. CONCLUSION: The use of silver-impregnated multi-lumen catheters in adult intensive care patients is not associated with a lower rate of colonization than the use of standard multi-lumen catheters. © 2007 Lippincott Williams & Wilkins, Inc.
Authors & Co-Authors
Kalfon, Pierre
France, Chartres
Hôpitaux de Chartres
de Vaumas, Cyrille
France, Paris
Hôpital Bichat-claude-bernard Ap-hp
Samba, Désiré
France, Caen
Hopital Cote de Nacre
Boulet, Éric
France, Cergy-pontoise
Centre Hospitalier René Dubos
Lefrant, Jean Yves
France, Nimes
Hôpital Universitaire Carémeau
Eyraud, Daniel
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Lherm, Thierry
France, Chartres
Hôpitaux de Chartres
Santoli, Francesco
France, Montreuil
Centre Hospitalier Intercommunal André Grégoire
Naïja, Walid
Tunisia, Sousse
Chu Sahloul
Riou, Bruno
France, Paris
Sorbonne Université
Statistics
Citations: 73
Authors: 10
Affiliations: 9
Identifiers
Doi:
10.1097/01.CCM.0000259378.53166.1B
ISSN:
00903493
Research Areas
Health System And Policy
Study Design
Cohort Study