Effect of lime juice (citrus aurantifolia) on histomorphological alterations of the ovaries and uterus of cyclic Sprague-Dawley rats

The aim of this study is to determine the effect of lime juice on histomorphological alterations of the ovaries and uterus of cyclic Sprague-Dawley rats. Materials and methods: Ten adult female Sprague-Dawley rats were used in this study. They were divided into 2 groups with 5 rats in each. The animals in group 1 received 1ml of undiluted lime juice on morning of proestrus and those in group 2 received distilled water only on the day of proestrus. Results: The number of ova shed in the treated rats was reduced when compared with the control group. The histological sections of the treated ovaries showed a smaller dimension with fewer ova when compared with the control. The ovarian follicles are not also seen at different stages of maturation and the mature follicles are essentially absent at the periphery and no prominent ova when compared with the control sections. The treated Effect of Lime Juice (Citrus Aurantifolia) on Histomorphological Alterations of the Ovaries and Uterus of Cyclic Sprague-Dawley Rats 608 uterine sections showed large luminal content and the uterine endometrium was lined with tall columnar cells, glandular and stroma hyperplasia. The control showed pseudo-stratified endometrial lining with several round glands and focal hyperplasia. Conclusion: Lime juice reduces the number of ova shed and also causes irregularity in the histology of the reproductive organs (ovaries and uterus) and may possibly compromise fertility. © EuroJournals Publishing, Inc. 2012.