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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Foot-and-mouth disease marker vaccine: Cattle protection with a partial VP1 G-H loop deleted virus antigen
Vaccine, Volume 29, No. 46, Year 2011
Notification
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Description
Contrary to the dogma that the VP1 G-H loop is essential for FMD vaccine efficacy, it has been previously shown that foot-and-mouth disease 146s antigen containing heterologous VP1 G-H loops confers complete protection in pigs and cattle. Moreover, serological evaluation of cattle vaccinated with an antigen lacking a large proportion of the VP1 G-H loop indicated that these animals should be protected against infection with FMD.Absence of this loop provides opportunity for the development of an FMD negative marker vaccine, allowing infection to be detected by antibodies against this missing region.Cattle vaccinated with this negative marker vaccine were fully protected following virus challenge 28 days post vaccination as determined by the absence of generalised lesions on their feet. Furthermore, use of our improved differentiation ELISA identified animals exposed to infection as early as 7 days post-challenge.We thus demonstrate, for the first time, the ability of this FMD negative marker vaccine to fully protect cattle from experimental challenge and rapidly distinguish animals that are subsequently exposed to infection. © 2011.
Authors & Co-Authors
Fowler, V. L.
United Kingdom, Surrey
The Pirbright Institute
Bashiruddin, John B.
United Kingdom, Surrey
The Pirbright Institute
Maree, Francois Frederick
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
Mutowembwa, Paidamwoyo Barry
South Africa, Onderstepoort
Onderstepoort Veterinary Institute
Bankowski, B.
United Kingdom, Surrey
The Pirbright Institute
Gibson, D.
United Kingdom, Surrey
The Pirbright Institute
Cox, S.
United Kingdom, Surrey
The Pirbright Institute
Knowles, Nick James
United Kingdom, Surrey
The Pirbright Institute
Barnett, Paul V.
United Kingdom, Surrey
The Pirbright Institute
Statistics
Citations: 21
Authors: 9
Affiliations: 2
Identifiers
Doi:
10.1016/j.vaccine.2011.08.035
ISSN:
0264410X
e-ISSN:
18732518