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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
Journal of the International AIDS Society, Volume 25, No. 3, Article e25871, Year 2022
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Description
Introduction: Adolescents living with HIV are subject to multiple co-morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project. Methods: Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height-for-age Z-scores (HAZ, stunting if <-2 SD, WHO growth charts). Linear mixed-effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex-specific models with fractional polynomials were used to model non-linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age. Results: A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two-thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub-Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia-Pacific; 19% overall had CD4 counts <500 cells/mm3. Across adolescence, higher HAZ was observed in females and among those in high-income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch-up with non-stunted, early ART-treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm3. This decline was observed across all regions, in males and females. Conclusions: Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood. © 2022 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8901148/bin/JIA2-25-e25871-s002.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC8901148/bin/JIA2-25-e25871-s001.docx
Authors & Co-Authors
Jesson, Julie
France, Toulouse
Cerpop - Centre D'epidémiologie et de Recherche en Santé Des Populations
Crichton, Siobhan L.
United Kingdom, London
Mrc Clinical Trials Unit
Quartagno, Matteo
United Kingdom, London
Mrc Clinical Trials Unit
Yotebieng, Marcel
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Abrams, Elaine J.
United States, New York
Columbia University
Chokephaibulkit, Kulkanya
Thailand, Nakhon Pathom
Mahidol University
Le Coeur, Sophie
France, Paris
Ined Institut National d' Études Démographiques
Thailand, Bangkok
Institute of Research for Development, Thailand
Aké-Assi, Marie Hélène
Cote D'ivoire, Abidjan
University Hospital Chu of Yopougon
Patel, Kunjal
United States, Boston
Harvard T.h. Chan School of Public Health
Pinto, Jorge Andrade
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Paul, Mary Elizabeth
United States, Houston
Texas Children's Hospital
Vreeman, Rachel Christine
United States, New York
Icahn School of Medicine at Mount Sinai
Davies, Mary Ann
South Africa, Cape Town
University of Cape Town
Ben-Farhat, Jihane
France, Paris
Epicentre
van Dyke, Russell B.
United States, New Orleans
Tulane University Health Sciences Center
Judd, Ali M.
United Kingdom, London
Mrc Clinical Trials Unit
Mofenson, Lynne M.
United States, Washington, D.c.
Elizabeth Glaser Pediatric Aids Foundation
Vicari, Marissa
Switzerland, Geneva
Unaids
Seage, George R.
Cote D'ivoire, Abidjan
University Hospital Chu of Yopougon
Bekker, Linda-Gail Gail
South Africa, Cape Town
Desmond Tutu Health Foundation
Essajee, Shaffiq M.
United States, New York
Unicef
Gibb, Diana M.
United Kingdom, London
Mrc Clinical Trials Unit
Penazzato, Martina
Switzerland, Geneva
Organisation Mondiale de la Santé
Collins, I. J.
United Kingdom, London
Mrc Clinical Trials Unit
Wools-Kaloustian, Kara K.
United States, Indianapolis
Indiana University School of Medicine
Slogrove, Amy L.
South Africa, Stellenbosch
Stellenbosch University
Powis, Kathleen M.
Cote D'ivoire, Abidjan
University Hospital Chu of Yopougon
Williams, Paige L.
Cote D'ivoire, Abidjan
University Hospital Chu of Yopougon
Matshaba, Mogomotsi S.
Botswana, Lilongwe
Baylor College of Medicine Children's Foundation
Thahane, Lineo Keneuoe
Lesotho, Maseru
Baylor College of Medicine Children's Foundation-lesotho
Nyasulu, Phoebe
Malawi, Lilongwe
Baylor College of Medicine Children's Foundation Malawi
Lukhele, Bhekumusa Wellington
Swaziland, Mbabane
Baylor College of Medicine Children's Foundation-swaziland
Mwita, Lumumba Francis
Tanzania, Mwanza
Baylor College of Medicine Children's Foundation-tanzania
Kekitiinwa-Rukyalekere, Adeodata
Uganda, Kampala
Baylor College of Medicine Children's Foundation
Wanless, Sebastian R.
Brazil, Belo Horizonte
Universidade Federal de Minas Gerais
Goetghebuer, Tessa
Belgium, Brussels
Centre Hospitalier Universitaire Saint Pierre, Brussels
Thorne, Claire N.
United Kingdom, London
University College London
Warszawski, Josiane
France, Villejuif
Centre de Recherche en Épidémiologie et Santé Des Populations
Galli, Luisa
Italy, Florence
Azienda Ospedaliero-universitaria Meyer
Italy, Florence
Università Degli Studi Di Firenze
Giaquinto, Carlo
Italy, Padua
Penta Foundation
Marczyńska, Magdalena
Poland, Warsaw
Sp Zoz Wojewódzki Szpital Zakazny - Centrum Diagnostyki I Terapii Aids, Warszawa
Marques, Laura Hora
Unknown Affiliation
Prata, Filipa X.Pina
Portugal, Lisbon
Santa Maria Hospital, Lisbon
Ene, Luminiţa
Romania, Bucharest
Victor Babes National Institute
Okhonskaya, Lyuba
Russian Federation, Saint Petersburg
Republican Clinical Hospital of Infectious Diseases
Navarro, Marisa Luisa
Spain, Madrid
Hospital General Universitario Gregorio Marañón
Frick, Antoinette
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Navèr, Lars
Sweden, Stockholm
Karolinska Institutet
Kahlert, Christian R.
Switzerland, St Gallen
Children's Hospital of Eastern Switzerland
Volokha, Alla P.
Ukraine, Kyiv
Shupyk National Healthcare University of Ukraine
Chappell, Elizabeth
United Kingdom, London
Mrc Clinical Trials Unit
Pape, Jean William
Haiti, Port-au-prince
Groupe D’étude Haïtien Sur le Sarcome de Kaposi et Les Infections Opportunistes
Rouzier, Vanessa A.
Haiti, Port-au-prince
Groupe D’étude Haïtien Sur le Sarcome de Kaposi et Les Infections Opportunistes
Marcelin, Adias
Haiti, Port-au-prince
Groupe D’étude Haïtien Sur le Sarcome de Kaposi et Les Infections Opportunistes
de Menezes Succi, Regina Célia M.
Brazil, Sao Paulo
Universidade Federal de São Paulo
Sohn, Annette H.
Thailand, Bangkok
Treat Asia/amfar-the Foundation for Aids Research
Kariminia, Azar
Australia, Sydney
Unsw Sydney
Edmonds, Andrew
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Lelo, Patricia V.M.
Democratic Republic Congo, Kinshasa
Pediatric Hospital Kalembe Lembe
Lyamuya, Rita Elias
Tanzania, Morogoro
Morogoro Regional Hospital
Ogalo, Edith Apondi
Kenya, Eldoret
Moi Teaching and Referral Hospital
Odhiambo, Frank Akoth
Kenya, Nairobi
Kenya Medical Research Institute
Haas, Andreas D.
Switzerland, Bern
University of Bern
Bolton, Carolyn
Zambia, Lusaka
Centre for Infectious Disease Research in Zambia
Muhairwe, Josephine A.
Zimbabwe, Lesotho
Solidarmed
Tweya, Hannock M.
Malawi, Lilongwe
Lighthouse Trust
Sylla, Mariam Moustapha
Mali, Bamako
Chu Gabriel-touré
D'Almeida, Marcelline
Benin, Cotonou
Centre National Hospitalier Universitaire Hubert Koutoukou Maga
A Renner, Lorna
Ghana, Accra
Korle bu Teaching Hospital
Abzug, Mark J.
United States, Aurora
The Children's Hospital, Aurora
Oleske, James M.
United States, Newark
Rutgers new Jersey Medical School
Purswani, Murli Udharam
United States, New York
Bronx-lebanon Hospital Center
Teasdale, Chloe A.
United States, New York
Columbia University
Nuwagaba-Biribonwoha, Harriet
United States, New York
Columbia University
Goodall, Ruth L.
United Kingdom, London
Mrc Clinical Trials Unit
Leroy, Valeriane
France, Toulouse
Cerpop - Centre D'epidémiologie et de Recherche en Santé Des Populations
Statistics
Citations: 7
Authors: 76
Affiliations: 63
Identifiers
Doi:
10.1002/jia2.25871
ISSN:
17582652
Research Areas
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Participants Gender
Female