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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Effects of amodiaquine hydrochloride and artemisinin on indomethacin-induced lipid peroxidation in rats
Pakistan Journal of Biological Sciences, Volume 11, No. 17, Year 2008
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Description
In this study, the effects of two antimalarials-amodiaquine hydrochloride and artemisinin were investigated in ulcerated albino rats of Wistar strain. Rats were treated with amodiaquine (30 mg kg-1) and Artemisinin (2.86 mg kg-1) for 24 h after formation of ulcers induced by indomethacin. Treatments with Amodiaquine Hydrochloride led to significantly increased gastric lesions while artemisinin led to significantly decreased gastric lesions. Also, amodiaquine hydrochloride seemed to elaborate the indomethacin induced effects on gastric juice volume, pH and acid output, while artemisinin attenuated these changes. The data indicates that the use of amodiaquine hydrochloride may be dangerous to the integrity of the stomach, especially in existing gastric ulcers, while artemisinin is mild and ameliorating, may result from their lipid peroxidation/apoptosis activity interference. © 2008 Asian Network for Scientific Information.
Authors & Co-Authors
Ajeigbe, Kazeem Olasunkanmi
Nigeria, Benin
Igbinedion University Okada
Olaleye, Samuel Babafemi
Nigeria, Ibadan
University of Ibadan
Nwobodo, Ed O.
Nigeria, Awka
Nnamdi Azikiwe University
Statistics
Citations: 6
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.3923/pjbs.2008.2154.2158
e-ISSN:
18125735
Research Areas
Cancer