Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Breast cancer in pre-menopausal women in West Africa: Analysis of temporal trends and evaluation of risk factors associated with reproductive life
Breast, Volume 22, No. 5, Year 2013
Notification
URL copied to clipboard!
Description
Background: In West Africa, trends and risk factors for breast cancer (BC) have been rarely studied. Methods: Here we have analyzed trends of BC over two periods in two population-based cancer registries, in Mali-Bamako (1987-1997; 1998-2009) and in The Gambia (1988-1997; 1998-2006). We have conducted a case-control study ( n=253 cases, 249 controls) on risk factors associated with reproductive life stratified by menopausal status in Bamako. Results: Between the two periods, BC incidence rates increased by 20% (incidence rate ratio (IRR) 1.20 (95% CI [1.07-1.35])) in Bamako, with an annual percentage change of 2% (95% CI [0.4-3.6]). The increase was of 30% in women under 55 years (IRR 1.30 (95% CI [1.14-1.60])). A similar pattern was observed in The Gambia for women under 50 years (IRR 1.47 (95% CI [1.07-2.01])). Overall, pre-menopausal breast cancer was predominant in both countries. In contrary to what is well established, case-control study showed that late age at menarche (>14 years) increased the risk of BC among pre-menopausal women (OR: 2.02 (95% CI [1.08-3.78])) while it tended to be protective in post-menopausal women (OR: 0.61 (95% CI [0.29-1.29])). Later age at a first pregnancy (>20 years) was associated with a reduction of risk in pre-menopausal women (OR: 0.41 (95% CI [0.18-0.89])). Conclusion: These results indicate that the burden of pre-menopausal BC is increasing in West African countries. These cancers appear to be associated with distinct reproductive risk factors, highlighting the need for better understanding the biological bases of early BC in African populations. © 2013 Elsevier Ltd.
Authors & Co-Authors
Sighoko, Dominique
France, Lyon
Centre International de Recherche Sur le Cancer
France, Villeurbanne
Université Claude Bernard Lyon 1
Kamaté, Bakarou
Mali, Bamako
Point g Hospital
Traoré, Cheick Bougadari
Mali, Bamako
Point g Hospital
Mallé, Brahima S.
Mali, Bamako
Point g Hospital
Coulibaly, Bourama
Mali, Bamako
Point g Hospital
Karidiatou, Agnès
Mali, Bamako
Point g Hospital
Diallo, Coulibaly
Mali, Bamako
Point g Hospital
Bah, Ebrima
France, Lyon
Centre International de Recherche Sur le Cancer
Gambia, Banjul
Gambia Hepatitis Intervention Study
McCormack, Valerie Ann
France, Lyon
Centre International de Recherche Sur le Cancer
Muwonge, Richard
France, Lyon
Centre International de Recherche Sur le Cancer
Bourgeois, Denis M.
France, Villeurbanne
Université Claude Bernard Lyon 1
Gormally, Emmanuelle
France, Lyon
Université de Lyon
Curado, Maria Paula
France, Dardilly
International Prevention Research Institute
Bayo, Siné
Mali, Bamako
Point g Hospital
Hainaut, Pierre L.
France, Lyon
Centre International de Recherche Sur le Cancer
Statistics
Citations: 47
Authors: 15
Affiliations: 6
Identifiers
Doi:
10.1016/j.breast.2013.02.011
ISSN:
09609776
Research Areas
Cancer
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Study Locations
Multi-countries
Gambia
Mali
Participants Gender
Female