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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Sexually transmitted diseases and human immunodeficiency virus control in malawi: A field study of genital ulcer disease
Journal of Infectious Diseases, Volume 171, No. 2, Year 1995
Notification
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Description
Men with genital ulcer disease (GUD) attending a clinic in Malawi were evaluated and treated with one of five drug regimens. Haemophilus ducreyi was isolated from 204 (26.2%) of 778 patients. Of 677 men, 198 (29.2%) had treponemes detected in ulcer material by direct immunofluorescence or had rapid plasma reagin reactivity of ≥1:8. Human immunodeficiency virus type 1 (HIV-l) seroprevalence was 58.9% overall and 75.8% among patients reporting a history of GUD (P <.001). By logistic regression analysis, HIV-l seropositivity was shown to impair ulcer healing (P =.003). Treatment failure rates for culture-proven chancroid were 19% for trimethoprim-ulfamethoxazole, 12.9% and 7.4%, respectively, for low- and high-dose erythromycin regimens, and 8.3% and 0, respectively, for low- and high-dose ciprofloxacin regimens. Herpes antigen was detected by EIA in 6 (23.1%) of 26 nonhealing ulcers. In Malawi, GUD should be managed as a syndrome to assure treatment of both syphilis and chancroid. © 1995 The University of Chicago.
Authors & Co-Authors
Behets, Frieda M.T.F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Liomba, George N.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Lule, Godfrey S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Dallabetta, Gina A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Hoffman, Irving F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Hamilton, Holli A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Moeng, Stoffel
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Malawi, Lilongwe
Ministry of Health Malawai
Malawi, Zomba
University of Malawi
United States, Durham
Fhi 360
Statistics
Citations: 8
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1093/infdis/171.2.451
ISSN:
00221899
e-ISSN:
15376613
Research Areas
Health System And Policy
Infectious Diseases
Sexual And Reproductive Health
Study Approach
Quantitative
Study Locations
Malawi
Participants Gender
Male