Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Acute changes in pulse pressure in relation to constituents of particulate air pollution in elderly persons
Environmental Research, Volume 117, Year 2012
Notification
URL copied to clipboard!
Description
An increased pulse pressure (difference between systolic and diastolic blood pressure) suggests aortic stiffening. The objective of this study was to examine the acute effects of both particulate matter (PM) mass and composition on blood pressure, among elderly persons.We carried out a panel study in persons living in elderly homes in Antwerp, Belgium. We recruited 88 non-smoking persons, 70% women with a mean age of 83 years (standard deviation: 5.2). Blood pressure was measured and a blood sample was collected on two time points, which were chosen so that there was an exposure contrast in ambient PM exposure. The elemental content of the collected indoor and outdoor PM 2.5 (particulate matter with an aerodynamic diameter <2.5μm) mass concentration was measured. Oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) on outdoor PM 10 (particulate matter with an aerodynamic diameter <10μm) were measured.Each interquartile range increase of 20.8μg/m 3 in 24-h mean outdoor PM 2.5 was associated with an increase in pulse pressure of 4.0mmHg (95% confidence interval: 1.8-6.2), in persons taking antihypertensive medication (n=57), but not in persons not using antihypertensive medication (n=31) (p for interaction: 0.02). Vanadium, iron and nickel contents of PM 2.5 were significantly associated with systolic blood pressure and pulse pressure, among persons on antihypertensive medication. Similar results were found for indoor concentrations. Of the oxy-PAHs, chrysene-5,6-dione and benzo[a]pyrene-3,6-dione were significantly associated with increases in systolic blood pressure and pulse pressure.In elderly, pulse pressure was positively associated with acute increases in outdoor and indoor air pollution, among persons taking antihypertensive medication. These results might form a mechanistic pathway linking air pollution as a trigger of cardiovascular events. © 2012 Elsevier Inc.
Authors & Co-Authors
Jacobs, Lotte
Belgium, Leuven
Ku Leuven
Buczyńska, Anna Jolanta
Belgium, Wilrijk
Departement of Chemistry
Walgraeve, Christophe
Belgium, Ghent
Universiteit Gent
Delcloo, Andy
Belgium, Brussels
Royal Meteorological Institute of Belgium
Potgieter-Vermaak, Sanja
Belgium, Wilrijk
Departement of Chemistry
South Africa, Johannesburg
University of the Witwatersrand
United Kingdom, Manchester
Manchester Metropolitan University
Van-Grieken, René E.
Belgium, Wilrijk
Departement of Chemistry
Demeestere, Kristof
Belgium, Ghent
Universiteit Gent
Dewulf, Jo
Belgium, Ghent
Universiteit Gent
Van Langenhove, Herman R.
Belgium, Ghent
Universiteit Gent
De Backer, Hugo
Belgium, Brussels
Royal Meteorological Institute of Belgium
Nemery, Bénoit Ben
Belgium, Leuven
Ku Leuven
Nawrot, Tim Steve
Belgium, Leuven
Ku Leuven
Belgium, Hasselt
Universiteit Hasselt
Statistics
Citations: 83
Authors: 12
Affiliations: 7
Identifiers
Doi:
10.1016/j.envres.2012.05.003
ISSN:
00139351
e-ISSN:
10960953
Research Areas
Environmental
Noncommunicable Diseases
Participants Gender
Female