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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Breakpoint structure reveals the unique origin of an interspecific chromosomal inversion (2La) in the Anopheles gambiae complex
Proceedings of the National Academy of Sciences of the United States of America, Volume 103, No. 16, Year 2006
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Description
Paracentric chromosomal inversions are major architects of organismal evolution and have been associated with adaptations relevant to malaria transmission in anopheline mosquitoes. The processes responsible for their origin and maintenance, still poorly understood, can be illuminated by analysis of inversion breakpoint sequences. Here, we report the breakpoint structure of chromosomal inversion 2La from the principal malaria vector Anopheles gambiae and its relatives in the A. gambiae complex. The distal and proximal breakpoints of the standard (2L+a) arrangement contain gene duplications: full-length genes and their truncated copies at opposite ends. Intact genes without pseudogene copies in the alternative arrangement (2La) imply that 2L+a is derived and was viable despite damage to genes, because duplication preserved gene function. A unique origin for the interspecific 2La inversion was challenged previously by indirect genetic evidence, but breakpoint sequences determined from members of the A. gambiae complex strongly suggest their descent from a single event. The derived position of 2L+a, long considered ancestral in this medically important group, has significant implications for the phylogenetic history and the evolution of vectorial capacity in the A. gambiae complex. © 2006 by The National Academy of Sciences of the USA.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC1458865/bin/pnas_0509683103_index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC1458865/bin/pnas_0509683103_1.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC1458865/bin/pnas_0509683103_2.pdf
Authors & Co-Authors
Sharakhov, Igor V.
United States, Notre Dame
University of Notre Dame
United States, Blacksburg
Virginia Polytechnic Institute and State University
White, Bradley J.
United States, Notre Dame
University of Notre Dame
Sharakhova, Maria V.
United States, Notre Dame
University of Notre Dame
United States, Blacksburg
Virginia Polytechnic Institute and State University
Kayondo, Jonathan K.
United States, Notre Dame
University of Notre Dame
Lobo, Neil Francis
United States, Notre Dame
University of Notre Dame
Santolamazza, Federica
Italy, Rome
Sapienza Università Di Roma
della Torre, Alessandra
Italy, Rome
Sapienza Università Di Roma
Simard, Frédéric R.
France, Marseille
Ird Institut de Recherche Pour le Developpement
Collins, Frank H.
United States, Notre Dame
University of Notre Dame
Besansky, Nora J.
United States, Notre Dame
University of Notre Dame
Statistics
Citations: 82
Authors: 10
Affiliations: 4
Identifiers
Doi:
10.1073/pnas.0509683103
ISSN:
00278424
Research Areas
Genetics And Genomics
Infectious Diseases