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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Steady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected ugandan adults
Journal of Acquired Immune Deficiency Syndromes, Volume 60, No. 3, Year 2012
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Description
We investigated the effect of food on the steady-state pharmacokinetics of lopinavir and ritonavir in 12 Ugandan patients receiving lopinavir coformulated with ritonavir (LPV/r) tablets using a crossover design. Intensive pharmacokinetic sampling was performed 7 days apart after LPV/r dosing under moderate fat, high fat, and fasted meal conditions. Lopinavir and ritonavir concentrations were determined by liquid chromatography and tandem mass spectrometry. Compared with the fasted state, a high fat meal reduced lopinavir and ritonavir area under the curve by 14% and 29%, respectively. With a moderate fat meal, area under the curve for both drugs was similar to the fasted state. © 2012 Lippincott Williams & Wilkins.
Authors & Co-Authors
Lamorde, Mohammed
Uganda, Kampala
Makerere University College of Health Sciences
Ireland, Dublin
Trinity College Dublin
Byakika-Kibwika, Pauline
Uganda, Kampala
Makerere University College of Health Sciences
Ireland, Dublin
Trinity College Dublin
Uganda, Kampala
Infectious Diseases Network for Treatment and Research in Africa
Boffito, Marta A.
United Kingdom, London
Chelsea and Westminster Hospital
Nabukeera, Lillian
Uganda, Kampala
Makerere University College of Health Sciences
Mayito, Jonathan
Uganda, Kampala
Makerere University College of Health Sciences
Ogwal-Okeng, Jasper Watson
Uganda, Kampala
Makerere University College of Health Sciences
Tjia, John F.
United Kingdom, Liverpool
University of Liverpool
Back, David J.
United Kingdom, Liverpool
University of Liverpool
Khoo, Saye Hock
United Kingdom, Liverpool
University of Liverpool
Ryan, Máirín A.A.
Ireland, Dublin
Trinity College Dublin
Merry, Concepta
Uganda, Kampala
Makerere University College of Health Sciences
Ireland, Dublin
Trinity College Dublin
Uganda, Kampala
Infectious Diseases Network for Treatment and Research in Africa
Ireland, Dublin
St James's Hospital
Statistics
Citations: 11
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1097/QAI.0b013e3182567a35
ISSN:
15254135
Research Areas
Food Security
Infectious Diseases