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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
IFN-γ-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection
Microbes and Infection, Volume 7, No. 1, Year 2005
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Description
IFN-γ-inducible protein 10 (IP-10/CXCL10) is a chemokine involved in delayed-type hypersensitivity and attraction of monocytes and activated T lymphocytes at inflammatory foci, whereas pentraxin 3 (PTX3) is part of the innate immune response. In the Republic of Guinea, 220 newly diagnosed, HIV-negative, pulmonary tuberculosis (TB) patients were studied together with 220 healthy household controls and 220 community controls. CXCL10 and PTX3 blood levels were assessed by ELISA at diagnosis, after 2 months and at the end of treatment. In untreated patients, both CXCL10 and PTX3 levels were higher (P < 0.0001) than in controls, although household controls had higher (P < 0.0001) CXCL10 and PTX3 levels than community controls, but lower (P < 0.0001) than those of patients. At the end of treatment, 186 cured patients showed reduction (P < 0.0001) in both CXCL10 and PTX3 levels. In 34 patients with treatment failure, both CXCL10 and PTX3 levels increased further. In five previously healthy households who developed TB during the follow-up and in two patients who relapsed after treatment, a remarkable increase in both CXCL10 and PTX3 plasma levels was observed. Active TB is associated with increased CXCL10 and PTX3 levels in the plasma. Although not specific for TB, measurement of these proteins may help the monitoring of disease activity and efficacy of therapy. © 2004 Elsevier SAS. All rights reserved.
Authors & Co-Authors
Azzurri, Annalisa
Italy, Florence
Università Degli Studi Di Firenze
Sow, Oumou Younoussa
Guinea
University Ignace Deen
Amedei, Amedeo
Italy, Florence
Università Degli Studi Di Firenze
Bah, Boubacar Sidy Sily
Guinea
University Ignace Deen
Diallo, Sadio
Guinea
University Ignace Deen
Peri, Giuseppe
Italy, Milan
Istituto Di Ricerche Farmacologiche Mario Negri
Benagiano, Marisa
Italy, Florence
Università Degli Studi Di Firenze
D'Elios, Mario Milco
Italy, Florence
Università Degli Studi Di Firenze
Mantovani, Alberto R.
Italy, Milan
Istituto Di Ricerche Farmacologiche Mario Negri
del Prete, Gianfranco Franco F.
Italy, Florence
Università Degli Studi Di Firenze
Statistics
Citations: 214
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1016/j.micinf.2004.09.004
ISSN:
12864579
Research Areas
Infectious Diseases
Study Design
Cohort Study
Study Locations
Guinea