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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Cytokine mRNA expression in Mycobacteriam ulcerans-infected human skin and correlation with local inflammatory response
Infection and Immunity, Volume 74, No. 5, Year 2006
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Description
Cytokine mRNA expression in biopsies of Mycobacterium ulcerans-infected human tissue was investigated using real-time PCR, and the findings were correlated with the clinical stages of disease and histopathologies. A broad range of cytokine mRNAs were detected in 16 early nodules and 28 late-stage ulcers, including those for the Th1 cytokines tumor necrosis factor alpha (TNF-α) and gamma interferon (IFN-γ) and the Th2 cytokine interleukin 10 (IL-10). IFN-γ was strongly expressed in both nodules and ulcers, suggesting that a Th1 response begins early in the disease. There was a significantly higher expression of IL-8 and other proinflammatory cytokines in results from 32 biopsies with neutrophilia than in those from 12 biopsies without acute inflammation. Ten tissue samples containing granulomas showed high mRNA expression for IFN-γ, IL-1β, IL-12p35, IL-12p40, IL-15, and TNF-α relative to 34 tissue samples without granulomas. These results suggest that the human immune response to M. ulcerans is similar to that seen with some other mycobacteria despite the presence of the toxin mycolactone in the tissues. Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Phillips, Richard Odame
Ghana, Kumasi
Komfo Anokye Teaching Hospital
United Kingdom, London
St George’s, University of London
Horsfield, Catherine J.
United Kingdom, London
St Thomas' Hospital
Mangan, J.
United Kingdom, London
St George’s, University of London
Laing, Kenneth G.
United Kingdom, London
St George’s, University of London
Etuaful, Samuel N.
Ghana
St. Martin's Catholic Hospital
Awuah, Peter C.
Ghana, Kumasi
Nkawie Government Hospital
Nyarko, Kofi Mensah
Ghana, Tepa
Tepa Government Hospital
Osei-Sarpong, F.
Ghana, Tepa
Tepa Government Hospital
Butcher, Philip D.
United Kingdom, London
St George’s, University of London
Lucas, Sebastian B.
United Kingdom, London
St Thomas' Hospital
Wansbrough-Jones, Mark H.
United Kingdom, London
St George’s, University of London
Statistics
Citations: 32
Authors: 11
Affiliations: 6
Identifiers
Doi:
10.1128/IAI.74.5.2917-2924.2006
ISSN:
00199567
Research Areas
Cancer